Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model
Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model
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DOI：
10.1006/bbrc.1998.9916
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发表时间：
1999-01-27
影响因子：
3.1
通讯作者：
Argilés, JM
中科院分区：
文献类型：
--
作者：
Carbó, N;Costelli, P;Argilés, JM
白藜芦醇给接种了快速生长肿瘤（吉田AH-130腹水肝癌）的大鼠，导致肿瘤细胞含量显著降低（25%）。这种双酚的作用与G(2)/M细胞周期阶段细胞数量的增加有关。有趣的是，肿瘤细胞群的流式细胞分析显示存在非整倍体峰值（占总数的28%），这表明白藜芦醇导致肿瘤细胞群凋亡，导致细胞数量减少。(C) 1999学术出版社。
Resveratrol administration to rats inoculated with a fast growing tumour (the Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25%) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G(2)/M cell cycle phase. Interestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which suggests that resveratrol causes apoptosis in the tumour cell population resulting in a decreased cell number. (C) 1999 Academic Press.