Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma
Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma
复制标题
DOI：
10.1111/j.1572-0241.2006.00364.x
复制
发表时间：
2006-01-01
影响因子：
9.8
通讯作者：
Bernardi, M
中科院分区：
文献类型：
--
作者：
Cantarini, MC;Trevisani, F;Bernardi, M
目的：本研究的目的是评估肝细胞癌是否发生在设置的B或C病毒infection.METHODS有不同的预后：我们进行了一项多中心病例对照研究，比较102对患者受肝炎B病毒或丙型肝炎病毒相关的肝细胞癌。患者性别匹配（男/女：84/18对）、年龄、中心和入组阶段、基础慢性肝病（肝硬化/慢性肝炎：97/5对），Child-Pugh分级（A/B/C：70/25/7对），肝细胞癌分期（非晚期/晚期：50/52对），并在可能的情况下，提供癌症诊断模式（75对：47对在监测期间，28对在监测之外）。在整个人群中，B型肝炎患者的预后往往比丙型肝炎患者差（p= 0.160），并且在晚期肝细胞癌患者中，该差异具有统计学显著性（p= 0.025）。病因、Child-Pugh分级、大体病理和甲胎蛋白是整个人群中显著的独立预后因素。这些预后因素的分布并没有不同的患者之间的B型肝炎或丙型肝炎，无论是在整个人口和在亚组中的先进的肝细胞carcinoma.CONCLUSION：肝炎B病毒相关的肝细胞癌有更大的侵略性比丙型肝炎病毒相关的肿瘤，成为临床表现，一旦他们已经达到了先进的阶段。
OBJECTIVES: The aim of this study was to assess whether hepatocellular carcinoma occurring in the setting of hepatitis B or C virus infection has different prognosis.METHODS: We performed a multicentric case-control study comparing 102 pairs of patients affected by hepatitis B virus- or hepatitis C virus-related hepatocellular carcinoma. Patients were matched for sex (male/female: 84/18 pairs), age, center, and period of enrollment, underlying chronic liver disease (cirrhosis/chronic hepatitis: 97/5 pairs), Child-Pugh class (A/B/C: 70/25/7 pairs), hepatocellular carcinoma stage (nonadvanced/advanced: 50/52 pairs) and, when possible, modality of cancer diagnosis (75 pairs: 47 during and 28 outside surveillance).RESULTS: In the whole population, patients with hepatitis B tended to have a poor prognosis than those with hepatitis C (p= 0.160), and this difference became statistically significant among the patients with an advanced hepatocellular carcinoma (p= 0.025). Etiology, Child-Pugh class, gross pathology, and alpha-fetoprotein were the significant independent prognostic factors in the whole population. The distribution of these prognostic factors did not differ between patients with hepatitis B or hepatitis C, both in the whole population and in the subgroup of advanced hepatocellular carcinomas.CONCLUSION: Hepatitis B virus-related hepatocellular carcinomas have a greater aggressiveness than hepatitis C virus-related tumors, which becomes clinically manifest once they have reached an advanced stage.