Glycolaldehyde induces apoptosis in a human breast cancer cell line
Glycolaldehyde induces apoptosis in a human breast cancer cell line
复制标题
DOI：
10.1016/s0003-9861(03)00334-5
复制
发表时间：
2003-09-01
影响因子：
3.9
通讯作者：
Benov, LT
中科院分区：
文献类型：
--
作者：
Al-Maghrebi, MA;Al-Mulla, F;Benov, LT
活化的吞噬细胞利用髓过氧化物酶生成乙醇醛、2-羟丙醛和丙烯醛。由于α -羟基和α， β -不饱和醛具有高活性，吞噬细胞介导的这些产物的形成可能在杀死细菌和肿瘤细胞中起作用。在乳腺癌细胞中，我们发现乙醇醛能使葡萄糖-6-磷酸脱氢酶、甘油醛-3-磷酸脱氢酶和铜、锌超氧化物歧化酶失活，抑制细胞生长，诱导细胞凋亡。这些结果提示乙醇醛可能是中性粒细胞抗肿瘤活性的重要介质。(C) 2003 Elsevier Inc.版权所有。
Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because alpha-hydroxy and alpha,beta-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity. (C) 2003 Elsevier Inc. All rights reserved.