Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity
Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity
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DOI：
10.1016/j.bmcl.2013.03.029
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发表时间：
2013-05-15
影响因子：
2.7
通讯作者：
Laine, Eric
中科院分区：
文献类型：
--
作者：
Hano, Christophe;Renouard, Sullivan;Laine, Eric
2型糖尿病（T2 DM）是全球常见病之一。亚麻籽是迄今为止膳食木酚素最丰富的来源（即，开环异落叶松树脂酚二葡糖苷），其已显示在动物模型中延迟T2 DM的发展。在此，我们提出了涉及亚麻籽衍生的木酚素抑制胰腺α-淀粉酶（EC 3.2.1.1）的作用机制的第一个证据，因此，亚麻籽衍生的木酚素可以构成用于预防和治疗T2 DM的有希望的营养药物。(C)2013爱思唯尔有限公司保留所有权利。
Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is by far the richest source of the dietary lignans (i.e., secoisolariciresinol diglucoside) which have been shown to delay the development of T2DM in animal models. Herein, we propose the first evidences for a mechanism of action involving the inhibition of the pancreatic alpha-amylase (EC 3.2.1.1) by flaxseed-derived lignans that could therefore constitute a promising nutraceutical for the prevention and the treatment of T2DM. (C) 2013 Elsevier Ltd. All rights reserved.