Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression
Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression
复制标题
DOI：
10.1007/s00441-018-2959-y
复制
发表时间：
2018-12
影响因子：
3.6
通讯作者：
M. Lee;R. Jayant
中科院分区：
文献类型：
--
作者：
M. Lee;R. Jayant
血脑屏障（BBB）是脑间质液和血液之间的结构和功能屏障;屏障维持神经功能所需的精确控制的生化环境。这种内皮细胞、巨噬细胞、周细胞和星形胶质细胞的集合形成神经血管单位，其是血脑屏障的结构和功能单位。肽通过由神经血管单位的毛细血管内皮细胞表达的转运系统进入和离开CNS。限制肽和蛋白质转运到脑中的是外排转运蛋白，如P-gp，其是存在于脑毛细血管内皮的腔侧的跨膜蛋白，并且其功能是促进药物从脑转运和排泄到血液中。已经开发了纳米载体系统以开发用于增强BBB运输的运输系统。最近的方法，提高内源性肽的表达进行了讨论。
The blood-brain barrier (BBB) is a structural and functional barrier between the interstitial fluid of the brain and the blood; the barrier maintains the precisely controlled biochemical environment that is necessary for neural function. This constellation of endothelial cells, macrophages, pericytes, and astrocytes forms the neurovascular unit which is the structural and functional unit of the blood-brain barrier. Peptides enter and exit the CNS by transport systems expressed by the capillary endothelial cells of the neurovascular unit. Limiting the transport of peptides and proteins into the brain are efflux transporters like P-gp are transmembrane proteins present on the luminal side of the cerebral capillary endothelium and their function is to promote transit and excretion of drugs from the brain to the blood. Nanocarrier systems have been developed to exploit transport systems for enhanced BBB transport. Recent approaches for enhancing endogenous peptide expression are discussed.