The role of MLL in hematopoiesis and leukemia
The role of MLL in hematopoiesis and leukemia
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DOI：
10.1097/00062752-200207000-00004
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发表时间：
2002-07-01
影响因子：
3.2
通讯作者：
Korsmeyer, SJ
中科院分区：
文献类型：
--
作者：
Ernst, P;Wang, J;Korsmeyer, SJ
MLL基因，也称为HRX或ALL-1，最初被鉴定为在急性淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）的特定亚型中的复发性染色体易位。MLL基因的相互重排在婴儿ALL和继发性AML中最常见。由于与婴儿白血病的独特关联以及白血病细胞的有趣的不成熟和混合谱系表型，作者推测野生型MLL基因在造血系统发育的早期起着重要作用。本文综述了野生型MLL蛋白功能的最新进展，特别是考虑到在造血系统发育中的潜在功能。小鼠功能获得和丧失模型为MLL的正常功能和致癌MLL融合蛋白的功能改变提供了线索。使用其他模式生物的生化和遗传方法也阐明了实现这些功能的机制。(C)2002年利平科特威廉姆斯威尔金斯公司
The MLL gene, also called HRX or ALL-1, was originally identified as a recurrent chromosomal translocation in particular subtypes of acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML). Reciprocal rearrangements of the MLL gene are most common in infant ALL and secondary AML. Because of the unique association with infant leukemia and the intriguingly immature and mixed lineage phenotype of leukemic cells, the authors speculate that the wild-type MLL gene plays an important role early in the development of the hematopoietic system. This article reviews recent progress in understanding the function of the wild-type MLL protein, with particular consideration of potential functions within the developing hematopoietic system. Murine gain- and loss-of-function models have provided clues to the normal functions of MLL and altered functions of oncogenic MLL fusion proteins. Biochemical and genetic approaches using other model organisms have also elucidated mechanisms by which these functions are achieved. (C) 2002 Lippincott Williams Wilkins, Inc.