Voltage-gated calcium channel alpha 2delta subunits: an assessment of proposed novel roles.
Voltage-gated calcium channel alpha 2delta subunits: an assessment of proposed novel roles.
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DOI：
10.12688/f1000research.16104.1
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发表时间：
2018-01-01
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影响因子：
--
通讯作者：
Dolphin, Annette C
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文献类型：
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作者：
Dolphin, Annette C
电压门控钙（CaV）通道与β和α 2 δ辅助亚基相关。本文将重点介绍α 2 δ蛋白家族的功能，该家族有四个成员。α 2 δ亚基的典型作用是在CaV 1和CaV 2通道上传递各种特性，增加质膜中这些通道的密度并增强其功能。最近，已经提出了α 2 δ蛋白质的各种非典型相互作用，其中一些涉及与α 2 δ的钙通道竞争或增加α 2 δ运输，而其他则介导与其钙通道功能完全无关的作用。本文将讨论的α 2 δ蛋白的新作用包括与低密度脂蛋白受体相关蛋白1（LRP 1）、血小板反应蛋白、α-神经毒素、朊病毒蛋白、大电导钾（BK）通道和N-甲基-d-天冬氨酸（NMDA）受体的相关性。
Voltage-gated calcium (CaV) channels are associated with beta and alpha2delta auxiliary subunits. This review will concentrate on the function of the alpha2delta protein family, which has four members. The canonical role for alpha2delta subunits is to convey a variety of properties on the CaV1 and CaV2 channels, increasing the density of these channels in the plasma membrane and also enhancing their function. More recently, a diverse spectrum of non-canonical interactions for alpha2delta proteins has been proposed, some of which involve competition with calcium channels for alpha2delta or increase alpha2delta trafficking and others which mediate roles completely unrelated to their calcium channel function. The novel roles for alpha2delta proteins which will be discussed here include association with low-density lipoprotein receptor-related protein 1 (LRP1), thrombospondins, alpha-neurexins, prion proteins, large conductance (big) potassium (BK) channels, and N-methyl-d-aspartate (NMDA) receptors.