Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.
Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.
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DOI：
10.1161/jaha.120.019338
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发表时间：
2021-03
影响因子：
5.4
通讯作者：
Pavlovic D
中科院分区：
文献类型：
--
作者：
Hall C;Gehmlich K;Denning C;Pavlovic D
心脏成纤维细胞是负责在心脏中沉积细胞外基质的主要细胞类型，为收缩心肌提供支持并促进无数生理信号传导过程。尽管纤维化在伤口愈合过程中的重要性，但过度的成纤维细胞增殖和活化可导致病理性重塑，驱动心力衰竭和心律失常的发作。我们对驱动心脏成纤维细胞活化和增殖的机制的理解正在扩大，并且它们对心肌细胞功能的直接和间接影响的证据正在积累。在这篇综述中，我们重点关注成纤维细胞向肌成纤维细胞转化的重要性以及心脏成纤维细胞与心肌细胞的串扰。我们还考虑了目前使用的模型来探索这些问题。
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.