Soy and fish oil intake and mortality in a Japanese community
Soy and fish oil intake and mortality in a Japanese community
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DOI：
10.1093/aje/kwf118
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发表时间：
2002-11-01
影响因子：
5
通讯作者：
Shimizu, H
中科院分区：
文献类型：
--
作者：
Nagata, C;Takatsuka, N;Shimizu, H
在日本岐阜市高山的13,355名男性和15,724名女性居民中，研究了鱼和豆制品的摄入量与随后的全因和特定死因死亡率之间的关系。1992年，使用有效的半定量食物频率问卷对包括大豆和鱼摄入量的饮食进行了评估。经过7年的跟踪，2062名参与者(1163名男性和899名女性)死亡。对于男性来说，在调整总能量和非饮食协变量后，豆制品总摄入量的最高和最低五分之一与总死亡率略有显著负相关(危险比=0.83，95%可信区间：0.69，1.01；趋势p=0.07)。在调整了非饮食协变量后，女性也观察到最高风险比低于最低大豆制品摄入量的五分之一(风险比=0.83，95%可信区间：0，68，1.02；趋势P=0.04)。对与总死亡率显著相关的饮食因素的额外调整并没有减弱这些联系，对于女性而不是男性，来自鱼类的n-3脂肪酸与总死亡率显著负相关。结果表明，大豆摄入量可能对总死亡率有温和但有益的影响。
The relation between intake of fish and soy products and subsequent all-cause and cause-specific mortality was examined in a cohort of 13,355 male and 15,724 female residents of Takayama, Gifu, Japan, A diet that included soy and fish intake was assessed in 1992 by using a validated semiquantitative food frequency questionnaire. Over 7 years of follow-up, 2,062 participants (1,163 men and 899 women) died. For men, the highest compared with the lowest quintile of total soy product intake was marginally significantly inversely associated with total mortality after adjustment for total energy and nondietary covariates (hazard ratio = 0.83, 95% confidence interval: 0.69, 1.01; p for trend = 0.07). After adjustment for nondietary covariates, a decreased hazard ratio for the highest compared with the lowest quintile of total soy product intake was also observed for women (hazard ratio = 0.83, 95% confidence interval: 0,68, 1.02; p for trend = 0.04). Additional adjustment for dietary factors significantly associated with total mortality did not attenuate these associations, For women but not for men, n-3 fatty acids from fish were significantly inversely associated with total mortality. Results showed that soy intake may have moderate but beneficial effects on total mortality.