The challenge of targeting metastasis.
The challenge of targeting metastasis.
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DOI：
10.1007/s10555-015-9586-9
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Kripke ML
中科院分区：
文献类型：
--
作者：
Fidler IJ;Kripke ML
对常规治疗有抗药性的转移瘤是癌症死亡的主要原因。在大多数患者中，在诊断时已经发生转移。因此，预防转移不太可能具有治疗益处。转移性肿瘤的生物学异质性是治疗的主要障碍。然而，转移瘤的生长和存活依赖于肿瘤细胞和宿主稳态机制之间的相互作用。除了肿瘤细胞外，靶向这些相互作用可以对现有的转移瘤产生协同治疗作用。
Metastases that are resistant to conventional therapy are the major cause of death from cancer. In most patients, metastasis has already occurred by the time of diagnosis. Thus, the prevention of metastasis is unlikely to be of therapeutic benefit. The biological heterogeneity of metastases presents a major obstacle to treatment. However, the growth and survival of metastases depend on interactions between tumor cells and host homeostatic mechanisms. Targeting these interactions, in addition to the tumor cells, can produce synergistic therapeutic effects against existing metastases.