The kinomes of apicomplexan parasites
The kinomes of apicomplexan parasites
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DOI：
10.1016/j.micinf.2012.04.007
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发表时间：
2012-08-01
影响因子：
5.8
通讯作者：
Doerig, Christian
中科院分区：
文献类型：
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作者：
Miranda-Saavedra, Diego;Gabaldon, Toni;Doerig, Christian
蛋白质磷酸化在顶复门寄生虫的生物学中起着重要作用。许多顶复门蛋白激酶与它们的哺乳动物直系同源物有很大不同，因此构成了潜在药物靶点的景观。在这里，我们整合了基因组，生物化学，遗传和进化信息，提供了一个完整的和最新的分析12顶复门激酶组。所有激酶组序列可通过Kinomer数据库获得。(C)2012巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.