Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response.
Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response.
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DOI：
10.5230/jgc.2016.16.1.1
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发表时间：
2016-03
影响因子：
2.5
通讯作者：
Kim KM
中科院分区：
文献类型：
--
作者：
Cho J;Kang MS;Kim KM
Epstein-Barr病毒相关胃癌（EBVaGC）是胃癌（GC）的四种亚型之一，最近由癌症基因组图谱提出了新的分类。EBVaGC具有几个临床病理特征，如较长的生存期和较高的淋巴上皮瘤样癌（LELC）和伴有克罗恩病样淋巴反应的癌的频率，这些特征将其与ebv阴性GC区分开来。GC中宿主细胞免疫反应的强度和模式与GC患者的预后显著相关，提示免疫反应和肿瘤微环境在GC的进展中起关键作用，尤其是EBVaGC。在这里，我们回顾了EBVaGC患者突出免疫反应的细胞和分子机制。在EBVaGC中，免疫应答相关基因表达的失调促进肿瘤内或肿瘤周围免疫细胞的显著浸润。程序性死亡受体配体1的表达已知在EBVaGC中增加，因此，它被认为是EBVaGC患者的一个有利预后因素，尽管一些支持这一说法的数据存在争议。总的来说，EBVaGC患者的宿主细胞免疫反应的潜在机制和临床意义尚未完全阐明。因此，有必要进一步研究肿瘤微环境在EBVaGC中的作用。
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (LELC) and carcinoma with Crohn's disease-like lymphoid reaction that distinguish it from EBV-negative GC. The intensity and pattern of host cellular immune response in GC have been found to significantly correlate with the prognosis of patients with GC, suggesting that immune reaction and tumor microenvironment have critical roles in the progression of GC, and in particular, EBVaGC. Here, we reviewed the cellular and molecular mechanisms underlying prominent immune reactions in patients with EBVaGC. In EBVaGC, deregulation of the expression of immune response-related genes promotes marked intra- or peritumoral immune cell infiltration. The expression of programmed death receptor-ligand 1 is known to be increased in EBVaGC, and therefore, it has been proposed as a favorable prognostic factor for patients with EBVaGC, albeit some data supporting this claim are controversial. Overall, the underlying mechanisms and clinical significance of the host cellular immune response in patients with EBVaGC have not been thoroughly elucidated. Therefore, further research is necessary to better understand the role of tumor microenvironment in EBVaGC.