INTRACELLULAR FORMS OF MENINGOPNEUMONITIS VIRUS
INTRACELLULAR FORMS OF MENINGOPNEUMONITIS VIRUS
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DOI：
10.1084/jem.100.6.575
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发表时间：
1954-01-01
影响因子：
15.3
通讯作者：
GAYLORD, WH
中科院分区：
文献类型：
--
作者：
GAYLORD, WH
细胞内脑膜炎病毒的电子显微镜照片显示了几种类型的颗粒，这些颗粒可能代表了生命周期的不同阶段。它们是（a）基本体--直径为250至300 μ的致密颗粒，具有非常致密的中心颗粒。(b)中间形式-密度小于基本体和更大。有三四百亩。在直径上，包含非常致密中心颗粒，并且通常具有2或3个限制区。(c)直径为400至500 μ的圆-具有单膜且无内部颗粒的均匀结构。它们通常是伸长的，并以出芽酵母细胞的方式在中心收缩。(d)方圆五六百亩。在直径上具有单膜。[long在这些结构中的一些中可能存在一个、两个和三个致密颗粒。（e）“较大”结构，圆形至椭圆形，其膜中通常具有不连续性或破裂。它们有时似乎有内部隔膜。从这些观察结果可以推断，该病毒可以通过二分裂或多个孢子内体繁殖，并且基本体是孢子样阶段。
Electron micrographs of intracellular meningopneumonitis virus have shown several types of particles which are presumably representative of different stages of a life cycle. They are (a) Elementary bodies-dense particles 250 to 300 mu in diameter with very dense central granules. (b) Intermediate forms - less dense than elementary bodies and larger. They are 300 to 400 mu. in diameter, contain a very dense central granule, and often have 2 or 3 limiting zones. (c) Circles 400 to 500 mu in diameter - homogeneous structures with single membranes and no internal granules. They are often elongated and constricted at the center in the manner of budding yeast cells. (d) Circles 500 to 600 mu. in diameter with single membranes.[long dash]One, two, and three dense granules may be present in some of these structures, (e) "Larger" structures, circular to elliptical, often with discontinuities or ruptures in their membranes. They sometimes seem to have internal septa. It has been inferred from these observations that the virus can multiply by binary fission or by multiple endosporu-lation and that elementary bodies are a spore-like stage.