A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles
A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles
复制标题
pH 响应 DNA 纳米机器控制的金纳米颗粒催化组装
DOI：
10.1039/c6cc03089k
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发表时间：
2016
影响因子：
4.9
通讯作者：
Haojun Liang
中科院分区：
文献类型：
--
作者：
Dongbao Yao;Hui Li;Yijun Guo;Xiang Zhou;Shiyan Xiao;Haojun Liang
Toehold介导的DNA链置置反应具有独特的可编程特性，可驱动金纳米颗粒（AUNPS）的催化组装。本文中，我们在基于DNA-Aunps的基于DNA - 链置二置的催化装配系统中引入了pH响应性三重结构，以添加额外的控制因子，即pH。在该催化系统中，AUNP的聚合速率可以受到内部因素（底物，目标等）和外部控制（pH梯度）的调节。该策略可用于构建pH诱导的DNA逻辑门和复杂的DNA网络，以及成像活细胞的瞬时pH变化。
The toehold-mediated DNA-strand-displacement reaction has unique programmable properties for driving the catalytic assembly of gold nanoparticles (AuNPs). Herein, we introduced a pH-responsive triplex structure into the DNA-strand-displacement-based catalytic assembly system of DNA–AuNPs to add an additional controlling factor, namely the pH. In this catalytic system, the aggregation rate of AuNPs could be regulated by both internal factors (concentrations of substrate, target, etc.) and an external control (pH gradient). This strategy can be used to construct pH-induced DNA logic gates and sophisticated DNA networks as well as to image instantaneous pH changes in living cells.