Diastereoselective Synthesis of the Indeno-Tetrahydropyridine Core Bearing a Diaryl-Substituted Stereogenic Quaternary Carbon Center of Haouamine B
Diastereoselective Synthesis of the Indeno-Tetrahydropyridine Core Bearing a Diaryl-Substituted Stereogenic Quaternary Carbon Center of Haouamine B
复制标题
带有二芳基取代的 Haouamine B 立体季碳中心的茚并四氢吡啶核的非对映选择性合成
DOI：
10.1039/c0cc04453a
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
and Yoshiki Morimoto
中科院分区：
文献类型：
--
作者：
Takeshi Tanaka;Hiromi Inui;Hiroshi Kida;Takeshi Kodama;Takuya Okamoto;Aki Takeshima;Yoshimitsu Tachi;and Yoshiki Morimoto
通过分子内Pd催化的α-C-芳基化反应，通过分子内Pd催化的芳基化反应，将乙烯基酰亚胺的官能团直接转化为C2-C25双键，有效地合成了细胞毒豪华胺B(2)的特征吲哚四氢吡啶核.
The characteristic indeno-tetrahydropyridine core of cytotoxic haouamine B (2) was efficiently synthesized featuring the diastereoselective construction of a diaryl-substituted stereogenic quaternary center by an intramolecular Pd-catalyzed α-C-arylation and subsequent direct conversion of the vinylogous imide function into the C2–C25 double bond by TsNHNH2.