Weight Cycling and Mortality in a Large Prospective US Study
Weight Cycling and Mortality in a Large Prospective US Study
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DOI：
10.1093/aje/kwr378
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发表时间：
2012-04-15
影响因子：
5
通讯作者：
Gapstur, Susan M.
中科院分区：
文献类型：
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作者：
Stevens, Victoria L.;Jacobs, Eric J.;Gapstur, Susan M.
在一些研究中，体重循环与死亡风险的增加有关，但很少有研究区分由故意减肥引发的体重循环与由疾病引发的体重循环。在1992年至2008年的癌症预防研究II营养队列中，对55,983名男性和66,655名女性的重量自行车与死亡的关联进行了研究。体重周期被定义为故意减掉10磅或更多磅(=4.5公斤)，然后恢复该体重，并在1992年注册时进行的问卷调查中报告了终身体重周期的次数。在2008年结束的后续行动中，共有15,138名男性和10,087名女性死亡。用COX比例风险回归模型估计危险比和95%可信区间。当仅根据年龄对模型进行调整时，体重循环与死亡率呈正相关(趋势与t；0.0001)。然而，在调整了体重指数和其他危险因素后，体重周期数较少(1-4周期)的死亡率略低(男性的风险比(HR)=0.93，95%可信区间(CI)：0.89，0.97；女性的风险比(HR)=0.93，95%可信区间(CI)：0.89，0.98)，而体重周期数(>；=20个周期)与死亡率无关(男性HR=1.03，95%CI：0.89，1.19；女性HR=0.99，95%CI：0.88，1.12)。这些结果并不支持与负重自行车相关的死亡风险增加。
Weight cycling has been associated with an increased risk of death in some studies, but few studies differentiated weight cycling initiated by intentional weight loss from that initiated by illness. The association of weight cycling with death was examined among 55,983 men and 66,655 women in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2008. A weight cycle was defined as an intentional loss of 10 or more pounds (>= 4.5 kg) followed by regain of that weight, and the lifetime number of weight cycles was reported on a questionnaire administered at enrollment in 1992. A total of 15,138 men and 10,087 women died during follow-up, which ended in 2008. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards regression models. When the models were adjusted for age only, weight cycling was positively associated with mortality (P for trend < 0.0001). However, after adjustment for body mass index and other risk factors, low numbers of weight cycles (1-4 cycles) were associated with slightly lower mortality rates (hazard ratio (HR) = 0.93, 95% confidence interval (CI): 0.89, 0.97 in men and HR = 0.93, 95% CI: 0.89, 0.98 in women), whereas high numbers of weight cycles (>= 20 cycles) were not associated with mortality (HR = 1.03, 95% CI: 0.89, 1.19 in men and HR = 0.99, 95% CI: 0.88, 1.12 in women). These results do not support an increased risk of mortality associated with weight cycling.