Interlayer Repulsion of Retinal Ganglion Cell Mosaics Regulates Spatial Organization of Functional Maps in the Visual Cortex
Interlayer Repulsion of Retinal Ganglion Cell Mosaics Regulates Spatial Organization of Functional Maps in the Visual Cortex
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DOI：
10.1523/jneurosci.1873-17.2017
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发表时间：
2017-12-13
影响因子：
5.3
通讯作者：
Paik, Se-Bum
中科院分区：
文献类型：
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作者：
Jang, Jaeson;Paik, Se-Bum
在高等哺乳动物中，神经元的定向调谐在初级视觉皮层中被组织成准周期性模式。我们以前的模型研究表明，皮层方向图的地形可能源于ON和OFF视网膜神经节细胞（RGC）马赛克的莫尔干涉，但没有考虑如何实现一致的空间周期的地图。在这里，我们解决这个问题的两个关键的发现RGC马赛克的发展：第一，RGC之间的同型本地排斥可以开发一个长距离的六边形周期性。第二，异型相互作用抑制了ON和OFF马赛克的对齐，并产生具有一致空间频率的周期性干涉图案图。为了验证我们的模型，我们定量分析了猫数据中的RGC镶嵌，并证实观察到的视网膜镶嵌显示出异型相互作用的证据，与之前的观点相反，ON和OFF镶嵌是独立发展的。
In higher mammals, orientation tuning of neurons is organized into a quasi-periodic pattern in the primary visual cortex. Our previous model studies suggested that the topography of cortical orientation maps may originate from moire interference of ON and OFF retinal ganglion cell (RGC) mosaics, but did not account for how the consistent spatial period of maps could be achieved. Here we address this issue with two crucial findings on the development of RGC mosaics: first, homotypic local repulsion between RGCs can develop a long-range hexagonal periodicity. Second, heterotypic interaction restrains the alignment of ON and OFF mosaics, and generates a periodic interference pattern map with consistent spatial frequency. To validate our model, we quantitatively analyzed the RGC mosaics in cat data, and confirmed that the observed retinal mosaics showed evidence of heterotypic interactions, contrary to the previous view that ON and OFF mosaics are developed independently.