Pathogenesis and clinical course of mixed calcium oxalate and uric acid nephrolithiasis.
Pathogenesis and clinical course of mixed calcium oxalate and uric acid nephrolithiasis.
复制标题
草酸钙与尿酸性混合肾结石的发病机制及临床经过。
DOI：
10.1038/ki.1982.183
复制
发表时间：
1982
影响因子：
19.6
通讯作者：
F. L. Coe
中科院分区：
文献类型：
--
作者：
S. Millman;A. L. Strauss;J. Parks;F. L. Coe
By direct measurement, urine from patients who form calcium oxalate stones was supersaturated abnormally with respect to calcium oxalate monohydrate but not supersaturated with respect to undissociated uric acid. Urine from patients who form uric acid stones was supersaturated excessively with undissociated uric acid but not calcium oxalate. Patients who form both calcium oxalate and uric acid stones, however, produce urine that is supersaturated with respect to both solid phases. Low urine pH was the primary factor that increased supersaturation with respect to undissociated uric acid. The formation of both calcium oxalate and uric acid stones appears to be explained by a dual abnormality of urine supersaturation.
