Thyroglobulin: a specific serum marker for the management of thyroid carcinoma
Thyroglobulin: a specific serum marker for the management of thyroid carcinoma
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DOI：
10.1016/j.cll.2004.01.001
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发表时间：
2004-03-01
影响因子：
1.7
通讯作者：
Ain, KB
中科院分区：
文献类型：
--
作者：
Whitley, RJ;Ain, KB
滤泡细胞源性甲状腺癌是最常见的内分泌肿瘤。大多数肿瘤表现出特殊的分化功能，包括对促甲状腺激素的反应性，碘离子的浓度和甲状腺球蛋白的释放。尽管这些功能中的每一个都可用于诊断和治疗工作，但识别能够为其诊断可靠性提供信心的技术和临床特征至关重要。甲状腺球蛋白测定具有影响其临床有用性和解释的独特且重要的特征。同样，使用它们的诊断策略必须反映它们的优点和局限性，包括抗甲状腺球蛋白自身抗体的常见问题。使用逆转录聚合酶链反应检测循环肿瘤细胞中mRNA的新方法具有其自身的独特问题，这阻碍了其广泛的临床采用。
Thyroid carcinomas of follicular cell origin are the most common endocrine neoplasms. Most tumors exhibit specific differentiated functions, including responsiveness to thyrotropin, concentration of iodide, and release of thyroglobulin. Although each of these functions can be used for diagnostic and therapeutic efforts, it is critical to discern the technical and clinical features that provide confidence in their diagnostic reliability. Thyroglobulin assays have unique and important characteristics that affect their clinical usefulness and interpretation. Likewise, diagnostic strategies that use them must reflect their strengths and limitations, including the common problem with antithyroglobulin autoantibodies. New approaches that use reverse transcription polymerase chain reaction detection of mRNA in circulating tumor cells have their own unique problems, which have prevented their widespread clinical adoption.