Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil
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DOI：
10.1016/j.toxlet.2014.06.018
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发表时间：
2014-12-01
影响因子：
3.5
通讯作者：
Menezes-Filho, Jose A.
中科院分区：
文献类型：
--
作者：
de Sousa Viana, Gustavo F.;de Carvalho, Chrissie F.;Menezes-Filho, Jose A.
锰是人体的一种必需元素，过量会导致神经毒性损伤。到目前为止，锰暴露评估还没有理想的生物标志物。本研究旨在利用非侵入性生物标志物调查暴露于环境中的成年人的锰暴露与神经心理效应之间的关系。对巴西巴伊亚一家锰铁精炼厂附近两个社区的居民进行了评估。志愿者年龄15~55岁，用电热吸收光谱法测定头发、腋毛、指甲和唾液中的锰含量。几项神经心理学测试被用来评估认知、注意力、记忆、运动和执行功能。头发(MNH，中位数8.95mU/g)、腋毛(MnAxH，18.49mU/g)和指甲(MnFN，6.91mU/g)中的锰与多项神经心理测试成绩呈显著正相关。未观察到唾液中锰水平(MnSal，4.2ug/L)与任何神经心理功能之间的关系。多元回归分析显示Log MNH与IQ呈负相关(β=-4.76[CI 95%-9.17至-0.36])，Log MnFN与视觉工作记忆呈负相关(Beta=-3.33[CI 95%-6.15至-0.52])。在认知灵活性任务中，Log MnFn与完成时间直接相关(β=56.29[CI 95%2.41-110.18])。使用非侵入性生物标志物的锰生物监测能够检测到高暴露水平，这与暴露于工业排放的成年人的有害神经心理影响有关。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
Manganese (Mn), an essential element to humans, in excess can cause neurotoxic damage. So far, Mn exposure assessment has no ideal biomarker. This study aims to investigate the association between Mn exposure, using noninvasive biomarkers, and neuropsychological effects in environmentally exposed adults. The residents of two communities near to a ferromanganese refinery in Bahia, Brazil were evaluated. Volunteers aged 15-55 of both sexes provided scalp hair, axillary hair, fingernail and saliva specimens for Mn determination by electrothermal absorption spectrometry. Several neuropsychological tests were used to evaluate cognitive, attention, memory, motor and executive functions. Significant correlations were observed between Mn in hair (MnH, median 8.95 mu g/g), axillary hair (MnAxH, 18.49 mu g/g) and fingernail (MnFN, 6.91 mu g/g) with the performances in several neuropsychological tests. No association was observed between manganese levels in saliva (MnSal, 4.2 mu g/L) and any neuropsychological function. Multiple regression analysis detected an inverse association between Log MnH and IQ (beta = -4.76 [CI 95% -9.17 to -0.36]) and between Log MnFN and visual working memory (beta = -3.33 [CI 95% -6.15 to -0.52]). Direct association was observed between Log MnFN and time of completion in the cognitive flexibility task (beta = 56.29 [CI 95% 2.41-110.18]). The Mn biomonitoring using noninvasive biomarkers was able to detect high exposure levels, which were associated with detrimental neuropsychological effects in adults exposed to industrial emissions. (C) 2014 Elsevier Ireland Ltd. All rights reserved.