C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study
C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study
复制标题
DOI：
10.1093/bja/aeq171
复制
发表时间：
2010-09-01
影响因子：
9.8
通讯作者：
Hall, G. M.
中科院分区：
文献类型：
--
作者：
Al-Subaie, N.;Reynolds, T.;Hall, G. M.
背景最近的研究发现，血浆C-反应蛋白（CRP）是一个预测结果出院后，从重症监护病房（ICU）。为了评估这一发现的普遍性，我们评估了ICU出院当天的CRP值作为计划外ICU再入院和2周内意外死亡的预测因子。出院时的血浆白蛋白和白色细胞计数也被认为是与持续炎症相关的标志物。方法。这是一项单中心观察性研究，涉及一所大学教学医院的内科-外科ICU。数据前瞻性地收集了1487个入院，涉及1401例患者在12个月的时间。从ICU出院之日起，收集患者的入院详情和APACHE II评分以及血浆CRP、白色细胞计数和白蛋白值。我们评估了再次入院、意外死亡和非意外死亡患者在这些变量上的差异。我们发现9.9%的出院患者要么再次入院（7.0%），要么意外死亡（2.9%）。再次入院的患者血浆白蛋白浓度较低[20（16，24）vs 22（19，27），P
Background. Recent studies have found plasma C-reactive protein (CRP) to be a predictor of outcome after discharge from the intensive care unit (ICU). To assess the generalizability of this finding, we assessed the value of CRP on the day of ICU discharge as a predictor of unplanned ICU readmission and unexpected death within 2 weeks. Plasma albumin and white cell count at discharge were also considered as markers associated with ongoing inflammation.Methods. This was a single-centre observational study involving a medical-surgical ICU in a university teaching hospital. Data were prospectively collected from 1487 admissions involving 1401 patients over a 12 month period. Patients' admission details and APACHE II score were collected in addition to plasma CRP, white cell count, and albumin values from the day of discharge from ICU. We assessed the difference in these variables between patients who were readmitted, who died unexpectedly, and those who did not.Results. We found that 9.9% of patients discharged were either readmitted (7.0%) or died unexpectedly (2.9%). Patients who were readmitted had a lower plasma albumin concentration [20 (16, 24) vs 22 (19, 27), P