MORPHOLOGICAL BASIS OF LONG-TERM HABITUATION AND SENSITIZATION IN APLYSIA
MORPHOLOGICAL BASIS OF LONG-TERM HABITUATION AND SENSITIZATION IN APLYSIA
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DOI：
10.1126/science.6828885
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
CHEN, M
中科院分区：
文献类型：
--
作者：
BAILEY, CH;CHEN, M
研究了长时习服和致敏缩鳃反射的持续突触可塑性的形态学基础。通过检查对照动物和通过训练改变行为的动物中感觉神经元突触前末梢（两种类型学习的短期形式的可塑性的关键部位）的精细结构来探索California。长期致敏动物的感觉神经元活性区的数量、大小和囊泡补体均大于对照动物，而长期习惯化动物的感觉神经元活性区则小于对照动物。这些变化可能代表了这些任务的记忆巩固的解剖学基础。
The morphological basis of the persistent synaptic plasticity that underlies long-term habituation and sensitization of the gill withdrawal reflex in A. californica was explored by examining the fine structure of sensory neuron presynaptic terminals (the critical site of plasticity for the short-term forms of both types of learning) in control animals and in animals whose behavior had been modified by training. The number, size and vesicle complement of sensory neuron active zones were larger in animals showing long-term sensitization than in control animals and smaller in animals showing long-term habituation. These changes are likely to represent an anatomical substrate for the memory consolidation of these tasks.