The effects of two forms of physical activity on eyeblink classical conditioning
The effects of two forms of physical activity on eyeblink classical conditioning
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DOI：
10.1016/j.bbr.2011.01.016
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发表时间：
2011-05-16
影响因子：
2.7
通讯作者：
Thanellou, Alexandra
中科院分区：
文献类型：
--
作者：
Green, John T.;Chess, Amy C.;Thanellou, Alexandra
自愿运动，比如在家里的笼子里自由地使用跑步轮，已经被证明可以改善几种形式的学习和记忆。杂技训练，以学习跨越高障碍的形式，已被证明可以诱导啮齿动物小脑皮层的神经可塑性标记物。在三个实验中，我们检查了这两种形式的体育活动对大鼠延迟眨眼条件反射的影响。在实验1中，运动大鼠在10天的延迟眨眼条件反射之前，在其家笼中自由使用17天的跑步轮。运动大鼠对眼周刺激的条件反射性反应明显优于未运动大鼠。在实验2中，运动的大鼠在10天明显不配对的刺激呈现之前，被给予17天自由使用笼子里的跑步轮。运动的大鼠对音调、光线和眼周刺激的反应与不运动的大鼠相同。在实验3中，杂技训练大鼠在进行10天的眨眼训练之前，每天进行15天的高障碍训练。活动控制的大鼠在一个开阔的场地上进行了15天的负重跑步。接受杂技训练的大鼠与活动控制的大鼠在眨眼条件反射方面没有区别。精确测量习得反应的能力，以及对眨眼条件反射的神经回路的良好映射，为研究运动对学习和记忆的影响提供了一些优势。(C) 2011 Elsevier B.V.版权所有
Voluntary exercise, in the form of free access to a running wheel in the home cage, has been shown to improve several forms of learning and memory. Acrobatic training, in the form of learning to traverse an elevated obstacle course, has been shown to induce markers of neural plasticity in the cerebellar cortex in rodents. In three experiments, we examined the effects of these two forms of physical activity on delay eyeblink conditioning in rats. In Experiment 1, exercising rats were given 17 days of free access to a running wheel in their home cage prior to 10 days of delay eyeblink conditioning. Rats that exercised conditioned significantly better and showed a larger reflexive eyeblink unconditioned response to the periocular stimulation unconditioned stimulus than rats that did not exercise. In Experiment 2, exercising rats were given 17 days of free access to a running wheel in their home cage prior to 10 days of explicitly unpaired stimulus presentations. Rats that exercised responded the same to tone, light, and periocular stimulation as rats that did not exercise. In Experiment 3, acrobatic training rats were given 15 days of daily training on an elevated obstacle course prior to 10 days of eyeblink conditioning. Activity control rats underwent 15 days of yoked daily running in an open field. Rats that underwent acrobatic training did not differ in eyeblink conditioning from activity control rats. The ability to measure the learned response precisely, and the well-mapped neural circuitry of eyeblink conditioning offer some advantages for the study of exercise effects on learning and memory. (C) 2011 Elsevier B.V. All rights reserved.