Neonatal capsaicin treatment increases the severity of ozone-induced lung injury.
Neonatal capsaicin treatment increases the severity of ozone-induced lung injury.
复制标题
新生儿辣椒素治疗会增加臭氧引起的肺损伤的严重程度。
DOI：
10.1164/ajrccm.153.1.8542155
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hyde,DM
中科院分区：
文献类型：
--
作者：
Sterner-Kock,A;Vesely,KR;Stovall,MY;Schelegle,ES;Green,JF;Hyde,DM
为了验证肺感觉C纤维保护小气道和肺泡免受氧化剂损伤的假设，我们比较了吸入臭氧(1ppm)或过滤空气8小时对四组大鼠的肺损伤和肺部炎症的影响：(1)正常大鼠暴露于过滤空气中；(2)正常大鼠暴露于臭氧中；(3)辣椒素(50 mg/kg)处理为新生大鼠，随后暴露于过滤空气中；以及(4)辣椒素处理为新生大鼠并随后暴露于臭氧中。所有大鼠在尸检前在过滤空气中恢复0、4、16和40h。暴露于过滤空气的大鼠(第1组和第3组)显示正常的呼吸道和实质结构。未处理的正常大鼠暴露在臭氧中，表现出轻微的间质炎症改变和支气管和细支气管上皮细胞的坏死。然而，用辣椒素处理的大鼠随后暴露在臭氧中，所有的呼吸道都出现了严重的急性间质炎症和上皮凝固性坏死，特别是在小的、外围的呼吸道和实质；所有这些变化都有统计学意义。这些发现支持我们的假设，即肺感觉C纤维在急性臭氧吸入期间保护远端呼吸道免受氧化剂损伤。
To test the hypothesis that lung sensory C fibers protect the small distal airways and alveoli from oxidant injury, we compared the effects of inhalation of ozone (1 ppm) or filtered air for 8 h on lung injury and lung inflammation in four groups of rats: (1) normal rats exposed to filtered air; (2) normal rats exposed to ozone; (3) rats treated as neonates with capsaicin (50 mg/kg, intraperitoneally) and subsequently exposed to filtered air; and (4) rats treated as neonates with capsaicin and subsequently exposed to ozone. All rats were allowed to recover in filtered air for 0, 4, 16, and 40 h before necropsy. Rats exposed to filtered air (Groups 1 and 3) showed normal airway and parenchyma structure. Normal untreated rats exposed to ozone showed a random distribution of mild, interstitial inflammatory changes and epithelial necrosis of bronchi and bronchiolar epithelium. However, rats treated with capsaicin and subsequently exposed to ozone demonstrated severe acute interstitial inflammation and epithelial coagulate necrosis in all airways, especially in small, peripheral airways and parenchyma; all of these changes were statistically significant. These findings support our hypothesis that lung sensory C fibers protect the distal airways from oxidant injury during acute ozone inhalation.