Studies on the susceptibility of the mouse preimplantation embryo to infection with cytomegalovirus.
Studies on the susceptibility of the mouse preimplantation embryo to infection with cytomegalovirus.
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小鼠着床前胚胎对巨细胞病毒感染的易感性研究。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
P. A. Neighbour
中科院分区：
文献类型：
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作者：
P. A. Neighbour
将完整且无透明带的小鼠植入前胚胎在不同发育阶段在体外暴露于鼠巨细胞病毒。胚胎正常发育至囊胚期，没有胚胎感染的证据。雌性小鼠腹膜内接种该病毒会产生急性全身感染，体内胚胎发育迟缓。胚胎本身没有被有效感染，当转移到未感染的小鼠体内时，它们发育成明显正常的胎儿。
Intact and zona-free mouse preimplantation embryos were exposed to murine cytomegalovirus in vitro at various stages of development. The embryos developed normally to the blastocyst stage, and there was no evidence of embryonic infection. Intraperitoneal inoculation of female mice with this virus produced an acute generalized infection, and embryonic development was retarded in vivo. The embryos themselves were not productively infected, and they developed into apparently normal fetuses when transferred to uninfected mice.