Microcalorimetric study of the effect of l-borneol, d-borneol and synthetic borneol on the growth of P-aeruginosa
Microcalorimetric study of the effect of l-borneol, d-borneol and synthetic borneol on the growth of P-aeruginosa
复制标题
左旋冰片、右旋冰片及合成冰片对铜绿假单胞菌生长影响的微量热研究
DOI：
10.1007/s10973-017-6627-3
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发表时间：
2018-02-01
影响因子：
4.4
通讯作者：
Dong, Taiwei
中科院分区：
文献类型：
--
作者：
Ma, Xiao;Xie, Qian;Dong, Taiwei
中医的属性理论已经被使用了几千年。冰片是一种重要的药物，被广泛用于治疗急性病。然而，在中国药典（chp）中，将冰片分为三种：l-冰片（B-1）， d-冰片（B-2）和合成冰片（B-3）。采用微量热法研究了冰片干扰下铜绿假单胞菌产生的功率-时间（P-t）曲线；然后，从曲线中得到一些热动力学参数来表征铜绿假单胞菌的代谢。采用主成分分析法对参数进行了分析。结果表明，冰片具有不同的药物性质。B-1的半最大影响浓度（IC50）值低于B-2和B-3。其中，B-1的IC50为447.185 μ g mL（-1）。三种冰片的影响分别为l-冰片（B-1）、b - 0合成冰片（B-3）、B-1 d-冰片（B-2），符合长期认知。为不同药物性质的冰片的临床应用提供指导。
Properties theory of traditional Chinese medicine has been used thousands of years. Borneol, an important drug, was widely used for acute illness-"Rebi" in Chinese. However, in Chinese Pharmacopoeia (Ch.P), borneol is recorded as three kinds: l-borneol (B-1), d-borneol (B-2) and synthetic borneol (B-3). In the study, the power-time (P-t) curves generated by P. aeruginosa which were disturbed by borneol were investigated through microcalorimetry; afterward, some thermo-kinetic parameters were obtained from the curves to characterize the metabolism of P. aeruginosa. The parameters were analyzed by principal component analysis. The results showed that borneol expressed different drugs properties. The half-maximal influences concentration (IC50) value of B-1 was lower than those of B-2 and B-3. Especially, the IC50 of B-1 was 447.185 mu g mL(-1). The influences of three kinds of borneol were l-borneol (B-1) > synthetic borneol (B-3) > d-borneol (B-2), which met the long-term cognition. This could provide guidance for clinical use of borneol with different drugs properties.