Sleep-dependent consolidation of auditory discrimination learning in adult starlings.
Sleep-dependent consolidation of auditory discrimination learning in adult starlings.
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DOI：
10.1523/jneurosci.4237-09.2010
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发表时间：
2010-01-13
期刊：
影响因子：
--
通讯作者：
Margoliash D
中科院分区：
文献类型：
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作者：
Brawn TP;Nusbaum HC;Margoliash D
人们普遍认为睡眠有助于记忆巩固。睡眠依赖性记忆巩固已在人类中广泛建立，出现在陈述性和程序性任务中。动物研究已经表明了各种可能作为睡眠依赖性巩固的神经基础的机制，例如清醒神经活动的离线重放以及睡眠期间特定睡眠参数或突触强度的调制。然而，记忆巩固不能仅从神经元事件推断，并且睡眠依赖性巩固的行为证明在动物中是有限的。在这里，我们调查了成年动物是否经历了与人类相似的睡眠依赖性记忆巩固。欧洲椋鸟（Sturnus vulgaris）进行了训练，以区分新的椋鸟歌曲的片段，并重新测试后，保留期，包括一个有规律的睡眠或只包括清醒。听觉辨别性能显着改善后保留期，包括睡眠，但不是在清醒后的时间，睡眠后的性能变化显着大于可比的清醒期后。因此，睡眠在成年椋鸟中产生的记忆益处模式与在人类中观察到的睡眠依赖性巩固模式基本相似，这表明在许多脊椎动物物种中存在一种共同的睡眠依赖性机制来巩固记忆，并为这种现象建立了一个强大的动物模型。
Memory consolidation is widely believed to benefit from sleep. Sleep-dependent memory consolidation has been established broadly in humans, appearing in declarative and procedural tasks. Animal studies have indicated a variety of mechanisms that could potentially serve as the neural basis of sleep-dependent consolidation, such as the offline replay of waking neural activity and the modulation of specific sleep parameters or synaptic strength during sleep. Memory consolidation, however, cannot be inferred from neuronal events alone, and the behavioral demonstration of sleep-dependent consolidation has been limited in animals. Here we investigated whether adult animals undergo sleep-dependent memory consolidation comparable to that of humans. European starlings (Sturnus vulgaris) were trained to discriminate between segments of novel starling song and retested after retention periods that included a regular night of sleep or consisted only of wakefulness. Auditory discrimination performance improved significantly after retention periods that included sleep but not after time spent awake, and the performance changes following sleep were significantly greater than after comparable periods of wakefulness. Thus, sleep produces a pattern of memory benefits in adult starlings that is fundamentally similar to the patterns of sleep-dependent consolidation observed in humans, suggesting a common sleep-dependent mechanism works across many vertebrate species to consolidate memories and establishing a robust animal model for this phenomenon.