Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging.
Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging.
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DOI：
10.1001/jamapsychiatry.2014.179
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发表时间：
2014-06
期刊：
影响因子：
25.8
通讯作者：
Peterson, Bradley S.
中科院分区：
文献类型：
--
作者：
Goh, Suzanne;Dong, Zhengchao;Zhang, Yudong;DiMauro, Salvatore;Peterson, Bradley S.
Impaired mitochondrial functioning impacts many biological processes that depend heavily on energy and metabolism, and it can lead to a wide range of neurodevelopmental disorders, including Autism Spectrum Disorders (ASD). Although evidence that mitochondrial dysfunction is a biological subtype of ASD has grown in recent years, no study has yet demonstrated evidence of mitochondrial dysfunction in brain tissue in vivo in a large, well-defined sample of individuals with ASD. (1) To assess brain lactate in individuals with ASD and typically developing controls using high-resolution, multi-planar spectroscopic imaging; (2) To map the distribution of lactate in the brains of individuals with ASD and assess correlations of elevated brain lactate with age, autism subtype, and intellectual ability. Case-control study Columbia University Medical Center and New York State Psychiatric Institute 75 children and adults with autism spectrum disorder and 96 age- and sex-matched, typically developing controls Lactate doublets (present or absent) on brain magnetic resonance spectroscopic imaging Lactate doublets were present at a significantly higher rate in participants with ASD (13%) than controls (1%) (p=.001). In the ASD group, the presence of lactate doublets correlated significantly with age (p=.004) and was detected more often in adults (20%) than in children (6%), though it did not correlate with sex, ASD subtype, intellectual ability, or ADOS total score or subscores. In those with ASD, lactate was detected most frequently within the cingulate gyrus, but it was also present in the subcortical gray matter nuclei, corpus callosum, superior temporal gyrus, and pre- and post-central gyri. These in vivo brain findings provide evidence for a possible neurobiological subtype of mitochondrial dysfunction in ASD.
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