Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma.

Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma.
复制标题

16 名成人 T 细胞白血病/淋巴瘤患者的白血病细胞的表型和功能分析。

DOI:
--
复制
发表时间:
1983
期刊:
影响因子:
20.3
通讯作者:
Y. Yamada
Y. Yamada
中科院分区:
医学1区
文献类型:
--
作者:
Y. Yamada

文献摘要

参考文献

被引文献

相似文献

应用抗Leu-1、抗Leu-2a、抗Leu-3a、抗HLA-DR和MAS 036 c单克隆抗体对16例成人T细胞白血病/淋巴瘤(ATLL)患者的白血病细胞进行了表面表型分析,并研究了白血病细胞对PWM诱导正常B细胞分化的影响。大多数ATLL细胞表面具有Leu-1和Leu-3a抗原,但缺乏Leu-2a抗原,与MAS 036 c不反应。这些结果表明,ATLL细胞是外周诱导/辅助T细胞的起源。然而,相反的表面表型,ATLL细胞从10例患者表现出有效的抑制活性PWM诱导的正常B细胞分化为免疫球蛋白产生细胞(Ig-PC),没有案件显示辅助活性。本文对ATLL细胞表面表型与功能的分离进行了讨论。
Surface phenotypes of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma (ATLL) were analyzed by using monoclonal antibodies (anti-Leu-1, anti-Leu-2a, anti-Leu-3a, anti-HLA-DR and MAS 036 c), and the effect of leukemic cells on PWM-induced normal B-cell differentiation was also studied. The majority of ATLL cells bear Leu-1 and Leu-3a antigen on cell surface but lack Leu-2a antigen and were unreactive with MAS 036 c. These results indicate that ATLL cells are of peripheral inducer/helper T-cell origin. However, contrary to the surface phenotype, ATLL cells from 10 patients showed potent suppressor activity on PWM-induced normal B-cell differentiation to immunoglobulin-producing cells (Ig-PC) and no case showed helper activity. The dissociation between surface phenotype and function of ATLL cells is discussed in this article.
DOI: --
发表时间: 1982
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Thomas,Y;Rogozinski,L;Irigoyen,OH;Shen,HH;Talle,MA;Goldstein,G;Chess,L
通讯作者: Chess,L
DOI: 10.1016/0090-1229(80)90072-0
发表时间: 1980
期刊: Clinical immunology and immunopathology
影响因子: --
作者:
Hopper,JE;Haren,JM
通讯作者: Haren,JM
同种异体混合白细胞反应中免疫球蛋白分泌细胞的诱导:人类辅助和抑制淋巴细胞亚群的调节。
DOI: --
发表时间: 1981
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Kotzin,BL;Benike,CJ;Engleman,EG
通讯作者: Engleman,EG
皮肤 T 细胞淋巴瘤:单克隆抗体表征。
DOI: --
发表时间: 1981
期刊: Blood
影响因子: 20.3
作者:
Kung,PC;Berger,CL;Goldstein,G;LoGerfo,P;Edelson,RL
通讯作者: Edelson,RL
DOI: --
发表时间: 1980
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Thomas,Y;Sosman,J;Irigoyen,O;Friedman,SM;Kung,PC;Goldstein,G;Chess,L
通讯作者: Chess,L