Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma.
Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma.
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16 名成人 T 细胞白血病/淋巴瘤患者的白血病细胞的表型和功能分析。
作者:
Y. Yamada
Surface phenotypes of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma (ATLL) were analyzed by using monoclonal antibodies (anti-Leu-1, anti-Leu-2a, anti-Leu-3a, anti-HLA-DR and MAS 036 c), and the effect of leukemic cells on PWM-induced normal B-cell differentiation was also studied. The majority of ATLL cells bear Leu-1 and Leu-3a antigen on cell surface but lack Leu-2a antigen and were unreactive with MAS 036 c. These results indicate that ATLL cells are of peripheral inducer/helper T-cell origin. However, contrary to the surface phenotype, ATLL cells from 10 patients showed potent suppressor activity on PWM-induced normal B-cell differentiation to immunoglobulin-producing cells (Ig-PC) and no case showed helper activity. The dissociation between surface phenotype and function of ATLL cells is discussed in this article.
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DOI:
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发表时间:
1982
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Thomas,Y;Rogozinski,L;Irigoyen,OH;Shen,HH;Talle,MA;Goldstein,G;Chess,L
通讯作者:
Chess,L
DOI:
10.1016/0090-1229(80)90072-0
发表时间:
1980
期刊:
Clinical immunology and immunopathology
影响因子:
--
作者:
Hopper,JE;Haren,JM
通讯作者:
Haren,JM
DOI:
--
发表时间:
1981
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Kotzin,BL;Benike,CJ;Engleman,EG
通讯作者:
Engleman,EG
影响因子:
20.3
作者:
Kung,PC;Berger,CL;Goldstein,G;LoGerfo,P;Edelson,RL
通讯作者:
Edelson,RL
DOI:
--
发表时间:
1980
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Thomas,Y;Sosman,J;Irigoyen,O;Friedman,SM;Kung,PC;Goldstein,G;Chess,L
通讯作者:
Chess,L