Brain: normal variations and benign findings in fluorodeoxyglucose-PET/computed tomography imaging.
Brain: normal variations and benign findings in fluorodeoxyglucose-PET/computed tomography imaging.
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DOI：
10.1016/j.cpet.2013.10.006
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发表时间：
2014-04
期刊：
影响因子：
2.6
通讯作者：
Pupi, Alberto
中科院分区：
文献类型：
--
作者：
Berti, Valentina;Mosconi, Lisa;Pupi, Alberto
脑18F-FDG PET允许脑葡萄糖代谢的体内研究，反映神经元和突触活动。18F-FDG PET已被广泛用于检测几种神经系统疾病与正常衰老的代谢变化。然而，健康受试者表现出18 F-FDG分布的变异，特别是与衰老相关的变异。18F-FDG摄取通常是均匀和对称的，但在基底神经节、额叶眼区、后扣带皮层和视觉皮层观察到略高的活性区域。相反，内侧颞叶皮层的代谢活动相对较低。本综述将重点介绍18F-FDG PET在所谓的正常大脑衰老中的发现，特别是随着年龄的增长和人们性别的变化而发生的代谢差异。将讨论不同物质，药物和治疗程序的影响，以及常见的工件。
Brain 18F-FDG PET allows the in vivo study of cerebral glucose metabolism, reflecting neuronal and synaptic activity. 18F-FDG PET has been extensively used to detect metabolic alterations in several neurological diseases vs. normal aging. However, healthy subjects exhibit variants of 18F-FDG distribution, especially as associated with aging. 18F-FDG uptake is usually homogeneous and symmetrical, but areas of slightly higher activity are observed in basal ganglia, frontal eye fields, posterior cingulate cortex and visual cortex. On the contrary, relatively lower metabolic activity is observed in medial temporal cortex. This review will focus on 18F-FDG PET findings in so-called normal brain aging, and in particular on metabolic differences occurring with aging and as a function of people’s gender. The effect of different substances, medications and therapy procedures will be discussed, as well as common artifacts.