Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL
Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL
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DOI：
10.1161/atvbaha.107.145474
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发表时间：
2007-11-01
影响因子：
8.7
通讯作者：
Pratico, Domenico
中科院分区：
文献类型：
--
作者：
Van Eck, Miranda;Hoekstra, Menno;Pratico, Domenico
目的：在本研究中，研究了SR-BI （HDL代谢的重要调节因子）的破坏对HDL相关抗氧化酶PON1和PAF-AH活性以及体内氧化应激的影响。方法与结果：sr - bi缺乏症的发生率为1.4倍(P
Objective-In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated.Methods and Results-SR-BI deficiency resulted in 1.4-fold (P