Circadian clocks, epigenetics, and cancer.
Circadian clocks, epigenetics, and cancer.
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DOI：
10.1097/cco.0000000000000153
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发表时间：
2015-01
影响因子：
3.4
通讯作者：
Sassone-Corsi P
中科院分区：
文献类型：
--
作者：
Masri S;Kinouchi K;Sassone-Corsi P
十多年来，人们一直认为昼夜节律与癌症之间存在相互作用，这是基于倒班工作与癌症发病率相关的观察结果。越来越多的证据表明，昼夜节律与癌症的生存和增殖途径有关。在分子水平上，已经提出了多种控制机制来将昼夜转录和细胞周期控制与肿瘤的发生联系起来。细胞周期的昼夜节律门控和随后的细胞增殖控制是一个活跃的研究领域。此外，生物钟是一个转录系统，在表观遗传水平上受到错综复杂的调控。有趣的是，组蛋白修饰、DNA甲基化和小调控RNA水平上的表观遗传格局在癌细胞中受到不同程度的控制。这一概念提出了一种可能性，即表观遗传控制是将时钟与癌症联系起来的常见线索，尽管迄今鲜有科学证据。这篇综述着重于生物钟与癌症之间的联系，并推测在表观遗传水平上可能存在的联系，可能进一步将生物钟与肿瘤的发生或进展联系起来。
The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways. At the molecular level, multiple control mechanisms have been proposed to link circadian transcription and cell-cycle control to tumorigenesis. The circadian gating of the cell cycle and subsequent control of cell proliferation is an area of active investigation. Moreover, the circadian clock is a transcriptional system that is intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape at the level of histone modifications, DNA methylation, and small regulatory RNAs are differentially controlled in cancer cells. This concept raises the possibility that epigenetic control is a common thread linking the clock with cancer, though little scientific evidence is known to date. This review focuses on the link between circadian clock and cancer, and speculates on the possible connections at the epigenetic level that could further link the circadian clock to tumor initiation or progression.