Have You Ever Seen the Impact of Crossing Fiber in DTI?: Demonstration of the Corticospinal Tract Pathway
Have You Ever Seen the Impact of Crossing Fiber in DTI?: Demonstration of the Corticospinal Tract Pathway
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DOI：
10.1371/journal.pone.0112045
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发表时间：
2015-07-02
期刊：
影响因子：
3.7
通讯作者：
Hong, Cheolpyo
中科院分区：
文献类型：
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作者：
Lee, Dong-Hoon;Park, Ji Won;Hong, Cheolpyo
由于皮质脊髓束（CST）的交叉纤维，尤其是手侧皮质脊髓束（CST）的交叉上级纵束（SLF），使得确定性纤维追踪方法对CST通路的识别受到限制。我们研究了先天性双侧大脑外侧裂周围综合征（CBPS）的患者谁没有SLF，为了可视化CST手纤维，不受交叉fibers.MethodsA 10岁的女孩没有SLF由于CBPS和三个正常的健康受试者参加了这项研究。我们采用确定性纤维追踪算法，在内囊后肢（PLIC）和初级运动皮层绘制感兴趣区（ROI）。根据提取的纤维束测量表观扩散系数（ADC）、各向异性分数（FA）、相对各向异性（RA）和体积比（VR）。正常人的FA、RA和VR值相似，但相对高于CBPS患者。结论我们的结果清楚地表明了交叉纤维对CST通路手部运动纤维的影响，并采用扩散张量纤维束成像中的确定性跟踪算法。
ObjectiveThe identification of the corticospinal tract (CST) pathway with a deterministic fiber tracking approach is limited because of crossing fibers, especially for the hand fibers of the CST due to the crossing superior longitudinal fasciculus (SLF). We examined a patient with congenital bilateral perisylvian syndrome (CBPS) who did not have the SLF, in order to visualize CST hand fibers that were not affected by crossing fibers.MethodsA 10-year-old girl without the SLF due to CBPS and three normal healthy subjects participated in this study. We used a deterministic fiber tracking algorithm, and the regions of interest (ROIs) were drawn in the posterior limb of internal capsule (PLIC) and the primary motor cortex. The apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), and volume ratio (VR) were measured based on the extracted fiber tracts.ResultsThe ADC values were not different between the normal subjects and the patient with CBPS. The FA, RA, and VR values of the normal subjects were similar, but were relatively higher than those of the patient with CBPS.ConclusionOur results clearly show the impact of the crossing fiber for the hand motor fibers of the CST pathway with deterministic tracking algorithms in diffusion tensor tractography.