PDX Finder: A portal for patient-derived tumor xenograft model discovery
PDX Finder: A portal for patient-derived tumor xenograft model discovery
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DOI：
10.1093/nar/gky984
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Bult, Carol C.
中科院分区：
文献类型：
--
作者：
Conte, Nathalie;Mason, Jeremy C.;Bult, Carol C.
患者来源的肿瘤异种移植(PDX)小鼠模型是一个通用的肿瘤学研究平台，用于研究肿瘤生物学和测试针对单个患者肿瘤的基因组特征的化疗方法。PDX模型由不同的学术实验室、多机构联盟和合同研究组织生成和分发。PDX资料库的分布式性质和使用不同的元数据标准来描述模型特征对识别与特定癌症研究问题相关的PDX模型提出了重大挑战。杰克逊实验室和EMBL-EBI正在通过共同开发PDX Finder来应对这些挑战，PDX Finder是一个全面开放的PDX模型及其相关数据集的全球目录。在PDX Finder中，使用以前开发的社区最小信息标准来协调和集成模型属性，以支持跨原始资源的一致搜索。PDX Finder搜索结果中提供了到存储库的链接，以促进模型获取和/或协作。PDX Finder资源目前包含各种癌症的1985年PDX模型的信息，包括来自患者衍生模型存储库、PDXNet和EurOPDX等大型资源的信息。我们邀请生成和分发PDX的个人或组织通过www.pdxfinder.org参与PDX Finder计划来提高其模型的可查找性。
Patient-derived tumor xenograft (PDX) mouse models are a versatile oncology research platform for studying tumor biology and for testing chemotherapeutic approaches tailored to genomic characteristics of individual patients' tumors. PDX models are generated and distributed by a diverse group of academic labs, multi-institution consortia and contract research organizations. The distributed nature of PDX repositories and the use of different metadata standards for describing model characteristics presents a significant challenge to identifying PDX models relevant to specific cancer research questions. The Jackson Laboratory and EMBL-EBI are addressing these challenges by co-developing PDX Finder, a comprehensive open global catalog of PDX models and their associated datasets. Within PDX Finder, model attributes are harmonized and integrated using a previously developed community minimal information standard to support consistent searching across the originating resources. Links to repositories are provided from the PDX Finder search results to facilitate model acquisition and/or collaboration. The PDX Finder resource currently contains information for 1985 PDX models of diverse cancers including those from large resources such as the Patient-Derived Models Repository, PDXNet and EurOPDX. Individuals or organizations that generate and distribute PDXs are invited to increase the findability' of their models by participating in the PDX Finder initiative at www.pdxfinder.org.