Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine.
Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine.
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DOI：
10.1371/journal.pone.0050648
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Takamura N
中科院分区：
文献类型：
--
作者：
Hayashida N;Sekitani Y;Takahashi J;Kozlovsky AA;Gutevych OK;Saiko AS;Nirova NV;Petrova AA;Rafalskiy RM;Chorny SA;Daniliuk VV;Anami M;Yamashita S;Takamura N
切尔诺贝利核电站（CNPP）事故发生后，儿童甲状腺癌的发病率有所增加。最近，在原子弹爆炸幸存者中显示出甲状腺实性结节与甲状腺癌发病率之间的密切关系。为了评估生活在乌克兰Zhitomir地区的个体良性甲状腺结节的预后，围绕CNPP，我们对1991年至2000年乌克兰的筛查数据进行了随访调查。研究对象为1991 ~ 2000年经超声初步诊断为甲状腺结节的160例（结节组）和160例无甲状腺结节的居民（正常对照组）。所有参与者年龄在0到10岁之间，事故发生时住在同一地区。我们对参与者进行随访筛查，并通过细针穿刺活检评估甲状腺结节。在结节组参与者中，与初始筛查相比，随访筛查时结节的数量和大小显著增加。在正常对照组参与者中未观察到甲状腺结节。结节组甲状腺异常率为7.5%，而正常对照组为0%（P<0.001），尤其是细针穿刺活检可疑癌性结节。我们的研究表明，儿童甲状腺结节是一个预后因素，与生活在乌克兰Zhitomir地区的个人结节的数量和大小增加有关。
After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. Recently, a strong relationship between solid thyroid nodules and the incidence of thyroid cancer was shown in atomic bomb survivors. To assess the prognosis of benign thyroid nodules in individuals living in the Zhitomir region of Ukraine, around the CNPP, we conducted a follow-up investigation of screening data from 1991 to 2000 in the Ukraine. Participants of this study were 160 inhabitants with thyroid nodules (nodule group) and 160 inhabitants without thyroid nodules (normal control group) intially identified by ultrasonography from 1991 to 2000. All participants were aged 0 to 10 years old and lived in the same area at the time of the accident. We performed follow-up screening of participants and assessed thyroid nodules by fine needle aspiration biopsy. Among the nodule group participants, the number and size of nodules were significantly increased at the follow-up screening compared with the initial screening. No thyroid nodules were observed among the normal control group participants. The prevalence of thyroid abnormality, especially nodules that could be cancerous (malignant or suspicious by fine needle aspiration biopsy), was 7.5% in the nodule group and 0% in the normal control group (P<0.001). Our study indicated that a thyroid nodule in childhood is a prognostic factor associated with an increase in the number and size of nodules in individuals living in the Zhitomir region of Ukraine.