Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging
Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging
复制标题
DOI：
10.1002/mrm.20438
复制
发表时间：
2005-04-01
影响因子：
3.3
通讯作者：
Sotak, CH
中科院分区：
文献类型：
--
作者：
Henning, EC;Meng, XJ;Sotak, CH
皮质扩散性抑制（CSD）可视化使用锰增强MRI（MEMRI）后，局部应用KCl暴露的大鼠皮质。在两次KCI应用后，同侧皮质相对于对侧对照区域的MEMRI信号增加为60 +/- 30%。单次（40%）与双次（80%）KCI应用的MEMRI信号增加表明连续CSD发作的整合效应。CSD诱导的MEMRI增强涉及皮质层含有致密的顶端树突区域，支持这些神经元结构是必要的CSD的传播的论点。海马和丘脑区域存在皮质下增强，最可能是与皮质层4和5的神经元连接的结果。这些结果与先前使用弥散加权MRI和T-2（*）加权MRI对CSD的研究一致，并应有助于研究CSD本身及其在其他神经系统疾病中的作用。Magn Reson Med 53：851-857，2005. (c)2005 WileyLiss，Inc.
Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCI to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCI applications. MEMRI signal increase for a single (40%) versus double (80%) KCI application suggests an integration effect over successive CSD episodes. CSD-induced MEMRI enhancement involved cortical layers containing dense regions of apical dendrites, supporting the contention that these neuronal structures are necessary for propagation of CSDs. Subcortical enhancement was present in hippocampal and thalamic regions, most likely a result of neuronal connections with cortical layers 4 and 5. These results are consistent with previous studies of CSD using diffusion-weighted MRI and T-2(*)-weighted MRI and should be useful for investigating CSD itself and its role in other neurologic disorders. Magn Reson Med 53:851-857, 2005. (c) 2005 WileyLiss, Inc.