Highlights in ultrasound-targeted microbubble destruction-mediated gene/ drug delivery strategy for treatment of malignancies
Highlights in ultrasound-targeted microbubble destruction-mediated gene/ drug delivery strategy for treatment of malignancies
复制标题
超声靶向微泡破坏介导的基因/药物递送策略治疗恶性肿瘤的亮点
DOI：
10.1016/j.ijpharm.2021.121412
复制
发表时间：
2022-01-05
影响因子：
5.8
通讯作者：
Nie, Fang
中科院分区：
文献类型：
--
作者：
Li, Hui;Zhang, Yao;Nie, Fang
超声是临床上应用最广泛、最安全、最先进的医学成像技术之一。传统上用于增强成像的超声微泡被越来越多地应用于超声靶向微泡破坏(UTMD)技术，该技术通过空化和超声操作来提高组织和细胞膜的通透性，从而产生一种有前景的治疗基因/药物传递策略。本文综述了UTMD介导的基因和药物传递在肿瘤诊断和治疗中应用的最新进展，包括UTMD的概念、作用机制、临床应用现状和优势。在此基础上，展望了该领域今后应重点关注的问题。
Ultrasound is one of the safest and most advanced medical imaging technologies that is widely used in clinical practice. Ultrasound microbubbles, traditionally used for contrast-enhanced imaging, are increasingly applied in Ultrasound-targeted Microbubble Destruction (UTMD) technology which enhances tissue and cell membrane permeability through cavitation and sonoporation, to result in a promising therapeutic gene/drug delivery strategy. Here, we review recent developments in the application of UTMD-mediated gene and drug delivery in the diagnosis and treatment of tumors, including the concept, mechanism of action, clinical application status, and advantages of UTMD. Furthermore, the future perspectives that should be paid more attention to in this field are prospected.