SYMPATHETIC ACTIVITY IN BROWN ADIPOSE-TISSUE IN LACTATING MICE
SYMPATHETIC ACTIVITY IN BROWN ADIPOSE-TISSUE IN LACTATING MICE
复制标题
DOI：
10.1152/ajpendo.1987.253.5.e515
复制
发表时间：
1987-11-01
影响因子：
--
通讯作者：
WUSTEMAN, MC
中科院分区：
文献类型：
--
作者：
TRAYHURN, P;WUSTEMAN, MC
通过测量哺乳期间小鼠肩胛间棕色脂肪组织的去甲肾上腺素周转率，评估了交感神经活动。从哺乳早期到断奶，棕色脂肪组织中的去甲肾上腺素周转率降低。周转率的减少发生在哺乳大型或小型窝仔的水坝中。自然断奶后去甲肾上腺素周转率恢复到对照水平，并在泌乳高峰期突然断奶后迅速增加。与对照动物一样，急性暴露于寒冷会导致哺乳期小鼠棕色脂肪组织中去甲肾上腺素的周转量大幅增加。这些结果表明，在哺乳期间，棕色脂肪组织中的交感神经活性受到抑制，但交感神经反应性得以保留。交感神经活动的减少可能是哺乳期棕色脂肪组织生热作用减少的原因。在哺乳高峰期，心脏中的去甲肾上腺素周转量往往会减少，这表明哺乳动物的交感神经活动可能普遍下降。与正常动物相反，哺乳期的食欲亢进不会导致交感神经系统的激活。
Sympathetic activity has been assessed, by measurements of norepinephrine turnover, in interscapular brown adipose tissue of mice during lactation. Norepinephrine turnover was reduced in brown adipose tissue from early lactation until weaning. The reduction in turnover occurred in dams suckling either large- or small-sized litters. Norepinephrine turnover returned to the control level after natural weaning and increased rapidly after abrupt wenaing at peak lactation. Acute exposure to cold resulted in a large increase in norepinephrine turnover in brown adipose tissue of lactating mice, as in control animals. These results indicate that sympathetic activity is suppressed in brown adipose tissue during lactation, but sympathetic responsiveness is retained. The reduction in sympathetic activity is likely to be responsible for the decrease in brown adipose tissue thermogenesis in lacation. Norepinephrine turnover in the heart tended to be reduced at peak lactation, suggesting that there may be a general decrease in sympathetic activity in the lactating animal. In contrast to the normal animal, the hyperphagia of lactation does not lead to an activation of the sympathetic nervous system.