Regulation of mitochondrial dynamics and neurodegenerative diseases.
Regulation of mitochondrial dynamics and neurodegenerative diseases.
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DOI：
10.18926/amo/43824
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发表时间：
2011-02
影响因子：
0.5
通讯作者：
Xiao-Jian Han;K. Tomizawa;A. Fujimura;I. Ohmori;T. Nishiki;M. Matsushita;H. Matsui
中科院分区：
文献类型：
--
作者：
Xiao-Jian Han;K. Tomizawa;A. Fujimura;I. Ohmori;T. Nishiki;M. Matsushita;H. Matsui
线粒体是大多数代谢过程中重要的细胞器，具有高度动态性，经常发生裂变和融合。裂变和融合之间的动态平衡在线粒体功能中起着至关重要的作用。在最近的研究中，几个大的gtpase已被确定为线粒体分裂和融合的关键分子因子。此外，这些大型gtpase的翻译后修饰，包括磷酸化、泛素化和sumo化，已被证明参与线粒体动力学的调节。由于神经元的能量需求大，过程长，因此对线粒体动力学异常特别敏感和脆弱。因此，新出现的证据表明，线粒体与神经退行性疾病，包括阿尔茨海默病、帕金森病和亨廷顿病之间存在很强的联系。在这篇综述中，我们将描述线粒体动力学的调节及其在神经退行性疾病中的作用。
Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases.