Relationship among Photopic Negative Response, Retinal Nerve Fiber Layer Thickness, and Visual Field between Normal and POAG Eyes.
Relationship among Photopic Negative Response, Retinal Nerve Fiber Layer Thickness, and Visual Field between Normal and POAG Eyes.
复制标题
光波负反应，视网膜神经纤维层厚度以及正常眼和POAG眼睛之间的视野之间的关系。
DOI：
10.1155/2013/182021
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Shen X;Huang L;Fan N;He J
目的。探讨正常和青光眼患者视网膜电图（ERG）光性负反应（PhNR）、视网膜神经纤维层（RNFL）厚度与视野的关系。方法。38名正常志愿者和124名原发性开角型青光眼（POAG）患者参加了这项研究。PhNRs是由白色背景的白色刺激和蓝色背景的红色刺激引起的。采用标准自动视距仪（SAP）测量视野参数。采用光谱域光学相干断层扫描（SD-OCT）测量视盘周围视网膜神经纤维层（RNFL）厚度。结果。POAG眼的PhNR振幅（W/W, B/R）、MD、平均RNFL厚度均显著低于正常眼（P = 0.001）。正常+青光眼组R值高于单纯青光眼组。MD和RNFL的PhNR振幅（B/R） R值高于PhNR振幅（W/W）。RNFL厚度与PhNR振幅（B/R）呈显著线性相关（r2 = 0.5, P = 0.001）。然而，MD与PhNR振幅（B/R）和RNFL厚度之间存在显著的曲线关联（r2 = 0.525, 0.442, P = 0.001）。结论。与宽频刺激相比，红光激发的PhNR能更有效地评估神经节细胞的活性。PhNR振幅与RNFL厚度的线性关系表明，青光眼视网膜内功能随神经功能丧失成比例下降。PhNR和RNFLT是比视野更客观的青光眼损伤检测工具。
Purpose. To determine the relationship among photopic negative response (PhNR) of the electroretinogram (ERG), retinal nerve fiber layer (RNFL) thickness, and the visual field in normal and glaucomatous patients. Methods. Thirty-eight normal volunteers and one hundred twenty-four patients with Primary open-angle glaucoma (POAG) were enrolled in the study. The PhNRs were elicited by white stimuli on a white background and red stimuli on a blue background. The visual field parameters were measured using the standard automated perimetry (SAP). The spectral domain optical coherence tomography (SD-OCT) was used to measure the retinal nerve fiber layer (RNFL) thickness around the optic disc. Results. The PhNR amplitude (W/W, B/R), MD, and mean RNFL thickness in POAG eyes were significantly lower than normal eyes (P = 0.001). The R value in Normal + Glaucomatous group was higher than that of the only glaucomatous group. The R values of PhNR amplitude (B/R) with MD and RNFL were higher than those of PhNR amplitude (W/W). Significant linear association was found in the relationship between RNFL thickness and PhNR amplitude (B/R) (R 2 = 0.5, P = 0.001). However, significant curve associations were found in the relationship between MD and PhNR amplitude (B/R) and RNFL thickness (R 2 = 0.525, 0.442, P = 0.001). Conclusions. The ganglion cell activity can be more efficiently evaluated with the PhNR elicited with a red than with a broadband stimulus. The linear relationship between the PhNR amplitude and RNFL thickness indicates that inner retinal function declines proportionately with neural loss in glaucomatous eyes. The PhNR and RNFLT are more objective tools to detect glaucomatous damage than visual field.