Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
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瘤内恒定自然杀伤 T 细胞和干扰素-γ 的组合与根治性切除后肝细胞癌的预后相关
DOI：
10.1371/journal.pone.0070345
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Xiao YS;Gao Q;Xu XN;Li YW;Ju MJ;Cai MY;Dai CX;Hu J;Qiu SJ;Zhou J;Fan J
目的探讨肿瘤内恒定自然杀伤T（iNKT）细胞和干扰素-γ（IFN-γ）对肝细胞癌（HCC）根治性切除术后预后的价值。采用实时定量聚合酶链反应（Real-time PCR）检测了224例肝癌根治性切除术患者肿瘤组织中编码iNKT细胞Vα24结构域的TRAV 10和IFN-γ mRNA的表达。这两个和其他临床病理因素的预后价值进行了评估。多变量考克斯比例风险分析显示，肿瘤内iNKT细胞和IFN-γ单独或联合是OS（P = 0.001）和RFS（P =0.001）的独立预后因素。 iNKT细胞和IFN-γ水平同时较低的患者的OS风险比（HR）为2.784，RFS风险比（HR）为2.673。应用受试者工作特征曲线分析，iNKT细胞、IFN-γ及其联合应用对死亡和复发的曲线下面积分别为0.618vs0.608vs0.654和0.591vs0.604vs0.633。iNKT细胞和IFN-γ水平低的HCC患者预后最差，这可能与pTNM分期较晚、血管浸润较多有关。肿瘤内iNKT细胞联合IFN-γ是一个有希望的HCC复发和生存的独立预测因子，与肿瘤内iNKT细胞或IFN-γ单独相比，其预测HCC患者预后的能力更强。
To investigate the prognostic value of intratumoral invariant natural killer T (iNKT) cells and interferon-gamma (IFN-γ) in hepatocellular carcinoma (HCC) after curative resection. Expression of TRAV10, encoding the Vα24 domain of iNKT cells, and IFN-γ mRNA were assessed by quantitative real-time polymerase chain reaction in tumor from 224 HCC patients undergoing curative resection. The prognostic value of these two and other clinicopathologic factors was evaluated. Either intratumoral iNKT cells and IFN-γ alone or their combination was an independent prognostic factor for OS (P = 0.001) and RFS (P = 0.001) by multivariate Cox proportional hazards analysis. Patients with concurrent low levels of iNKT cells and IFN-γ had a hazard ratio (HR) of 2.784 for OS and 2.673 for RFS. The areas under the curve of iNKT cells, IFN-γand their combination were 0.618 vs 0.608 vs 0.654 for death and 0.591 vs 0.604 vs 0.633 for recurrence respectively by receiver operating characteristic curve analysis. The prognosis was the worst for HCC patients with concurrent low levels of iNKT cells and IFN-γ, which might be related with more advanced pTNM stage and more vascular invasion. Combination of intratumoral iNKT cells and IFN-γ is a promising independent predictor for recurrence and survival in HCC, which has a better power to predict HCC patients’ outcome compared with intratumoral iNKT cells or IFN-γ alone.
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DOI：
10.1084/jem.20031462
发表时间：
2004-05-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Metelitsa LS;Wu HW;Wang H;Yang Y;Warsi Z;Asgharzadeh S;Groshen S;Wilson SB;Seeger RC
通讯作者：
Seeger RC
影响因子：
6.4
作者：
Margalit, M;Shibolet, O;Ilan, Y
通讯作者：
Ilan, Y
影响因子：
45.3
作者：
Molling, Johan W.;Langius, Jacqueline A. E.;van den Eertwegh, Alfons J. M.
通讯作者：
van den Eertwegh, Alfons J. M.
影响因子：
6.4
作者：
Miyagi, T;Takehara, T;Hayashi, N
通讯作者：
Hayashi, N
PD-L1 的过度表达与人类肝细胞癌的肿瘤侵袭性和术后复发显着相关。
影响因子：
11.5
作者：
Gao, Qiang;Wang, Xiao-Ying;Fan, Jia
通讯作者：
Fan, Jia