A novel method for fast imaging of brain function, non-invasively, with light
A novel method for fast imaging of brain function, non-invasively, with light
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DOI：
10.1364/oe.2.000411
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发表时间：
1998-05-11
期刊：
影响因子：
3.8
通讯作者：
Thomas, R
中科院分区：
文献类型：
--
作者：
Chance, B;Anday, E;Thomas, R
通过任何非侵入性技术对人体进行成像已经成为物理学和医学的适当目标，并且在脑成像中利用磁共振成像（MRI）和正电子发射断层扫描（PET）两者已经获得了巨大成功。在1993年（Chance等人[1]）和1994年（Tamura等人[2]）获得的使用脑近红外光谱（fNIR）的功能激活的非成像反应，现在补充了成人和早产儿的前额叶和顶叶刺激图像（另见[3]）。以前的研究使用连续[4]、脉冲[3]或调制[5]光。如针对单源检测器对所展示的光学图案的振幅和相位抵消提供了模型系统中的小物体检测的显著灵敏度[6]。这些方法现在已经用多源探测器组合（九个源，四个探测器）进行了详细说明。使用简单的反投影算法，现在可以及时成像成人和早产儿和足月新生儿人脑功能的感觉运动和认知激活
Imaging of the human body by any non-invasive technique has been an appropriate goal of physics and medicine, and great success has been obtained with both Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) in brain imaging. Non-imaging responses to functional activation using near infrared spectroscopy of brain (fNIR) obtained in 1993 (Chance, et al. [1]) and in 1994 (Tamura, et al. [2]) are now complemented with images of pre-frontal and parietal stimulation in adults and pre-term neonates in this communication (see also [3]). Prior studies used continuous [4], pulsed [3] or modulated [5] light. The amplitude and phase cancellation of optical patterns as demonstrated for single source detector pairs affords remarkable sensitivity of small object detection in model systems [6]. The methods have now been elaborated with multiple source detector combinations (nine sources, four detectors). Using simple back projection algorithms it is now possible to image sensorimotor and cognitive activation of adult and pre- and full-term neonate human brain function in times