Mortality due to amyotrophic lateral sclerosis and Parkinson's disease among melanoma patients
Mortality due to amyotrophic lateral sclerosis and Parkinson's disease among melanoma patients
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DOI：
10.1159/000097851
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发表时间：
2007-01-01
影响因子：
5.7
通讯作者：
Freedman, D. M.
中科院分区：
文献类型：
--
作者：
Baade, P. D.;Fritschi, L.;Freedman, D. M.
最近在美国和其他地方的研究已经确定了帕金森病（PD），肌萎缩侧索硬化症（ALS）和黑色素瘤之间的可能关联。然而，经验证据非常有限。我们对自1982年以来在澳大利亚诊断为黑色素瘤的所有人进行了研究（n = 127，037）。受试者（不包括在诊断后12个月内死亡的受试者）随访至2001年12月31日。然后，我们将他们的ALS和PD死亡风险与普通人群进行了比较。共有53例ALS死亡和129例PD死亡。虽然绝对风险很小，但黑色素瘤队列因ALS死亡的风险比一般人群高70%（标准化死亡率比= 169.4，95% CI = 127-221），死于PD的风险增加近3倍（标准化死亡率比= 266.3，95% CI = 222-317）。这些增加的风险对长期幸存者来说仍然存在，反对监测效应（特别是ALS）。在2个不同人群（澳大利亚和美国）中这些结果的一致性加强了黑色素瘤与2种神经退行性疾病之间相关性的证据。版权所有（c）2007 S. Karger AG，巴塞尔。
Recent studies in the USA and elsewhere have identified a possible association between Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and melanoma. However, empirical evidence is very limited. We conducted a study of all people diagnosed as having melanoma in Australia since 1982 (n = 127,037). The subjects, excluding those who had died within 12 months of diagnosis, were followed until 31 December 2001. We then compared their mortality risk of ALS and PD to that of the general population. There were a total of 53 ALS deaths and 129 deaths due to PD. Although the absolute risk is small, the melanoma cohort had a risk of death due to ALS 70% higher (standardised mortality ratio = 169.4, 95% CI = 127-221) than the general population, and nearly a 3-fold increased risk of dying from PD (standardised mortality ratio = 266.3, 95% CI = 222-317). These increased risks continued for long-term survivors, arguing against a surveillance effect (particularly for ALS). The consistency of these results in 2 separate populations (Australia and USA) strengthens the evidence for an association between melanoma and each of the 2 neurodegenerative diseases. Copyright (c) 2007 S. Karger AG, Basel.