Cigarette smoke exposure stimulates prostatic fibrosis and the potential protective functions of green tea epigallocatechin-3-gallate via regulating Hedgehog pathway
Cigarette smoke exposure stimulates prostatic fibrosis and the potential protective functions of green tea epigallocatechin-3-gallate via regulating Hedgehog pathway
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香烟烟雾暴露刺激前列腺纤维化以及绿茶表没食子儿茶素-3-没食子酸酯通过调节刺猬通路的潜在保护功能
DOI：
10.1016/j.jff.2020.103795
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发表时间：
2020-03-01
影响因子：
5.6
通讯作者：
Liu, Min
中科院分区：
文献类型：
--
作者：
Chen, Jinglou;Lei, Yongfang;Liu, Min
香烟消费在全世界都很流行。与此同时，绿色茶因其健康益处而被广泛接受。表没食子儿茶素没食子酸酯（Epigallocatechin-3-gallate，EGCG）是绿色茶中含量最丰富的儿茶素。本研究旨在探讨香烟烟雾暴露对人前列腺细胞和大鼠前列腺细胞的影响以及表没食子儿茶素没食子酸酯（EGCG）的潜在保护作用。结果表明，慢性CS暴露刺激前列腺上皮间质转化（EMT），胶原沉积和纤维化。下调Hedgehog（HH）信号通路有助于改善CS诱导的前列腺缺陷。同时，EGCG对前列腺纤维化有较强的抑制作用。其机制可能与调节EMT和降低HH信号通路活性有关。
Cigarettes consumption is popular all over the world. In the meantime, green tea is widely accepted for their health benefits. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. This study aimed to investigate the effects of cigarette smoke (CS) exposure on human prostate cells and rat prostate, as well as the potential protective functions of EGCG. The results suggested that chronic CS exposure stimulated prostatic epithelial-mesenchymal transition (EMT), collagen deposition and fibrosis. Down-regulation of the Hedgehog (HH) signaling pathway helped to ameliorate CS-induced prostatic deficits. Meanwhile, EGCG could exhibit strong anti-fibrosis effects on prostate. Its underlying mechanisms were related to modulate EMT and decrease the activity of HH signal pathway.