Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.
Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.
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DOI：
10.2147/oajsm.s123529
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发表时间：
2017
影响因子：
2.4
通讯作者：
Zello GA
中科院分区：
文献类型：
--
作者：
Chilibeck PD;Kaviani M;Candow DG;Zello GA
随着年龄的增长，肌肉质量和力量的丧失会导致严重的功能障碍。肌酸补充剂已与阻力训练结合使用，作为增加老年人瘦组织质量和肌肉力量的策略，但各项研究的结果是模棱两可的。我们通过搜索 PubMed 和 SPORTDiscus 数据库，对老年人阻力训练期间补充肌酸的随机对照试验进行了系统回顾和荟萃分析，以瘦组织质量、胸部按压力量和腿部按压力量为结果。我们的荟萃分析中纳入了 22 项研究，涉及 721 名参与者（男性和女性；所有研究的平均年龄为 57-70 岁），在每周 2-3 天的阻力训练期间随机接受肌酸补充剂或安慰剂，持续 7-52 周。补充肌酸导致瘦组织质量（平均差 = 1.37 kg [95% CI = 0.97–1.76]；p<0.00001）、胸部按压力量（标准化平均差 [SMD] = 0.35 [0.16–0.53]；p=0.0002）和腿部按压力量（SMD = 0.24 [0.05–0.43]；p = 0.0002）的更大增加。 p=0.01）。肌酸可以通过多种机制增加瘦肉组织质量和肌肉力量。这些内容包含在本文讨论部分的叙述性评论中。总之，补充肌酸可以增加老年人阻力训练期间的瘦组织质量以及上半身和下半身的肌肉力量，但肌酸发挥这些积极作用的潜在机制尚未得到广泛评估。
The loss of muscle mass and strength with aging results in significant functional impairment. Creatine supplementation has been used in combination with resistance training as a strategy for increasing lean tissue mass and muscle strength in older adults, but results across studies are equivocal. We conducted a systematic review and meta-analysis of randomized controlled trials of creatine supplementation during resistance training in older adults with lean tissue mass, chest press strength, and leg press strength as outcomes by searching PubMed and SPORTDiscus databases. Twenty-two studies were included in our meta-analysis with 721 participants (both men and women; with a mean age of 57–70 years across studies) randomized to creatine supplementation or placebo during resistance training 2–3 days/week for 7–52 weeks. Creatine supplementation resulted in greater increases in lean tissue mass (mean difference =1.37 kg [95% CI =0.97–1.76]; p<0.00001), chest press strength (standardized mean difference [SMD] =0.35 [0.16–0.53]; p=0.0002), and leg press strength (SMD =0.24 [0.05–0.43]; p=0.01). A number of mechanisms exist by which creatine may increase lean tissue mass and muscular strength. These are included in a narrative review in the discussion section of this article. In summary, creatine supplementation increases lean tissue mass and upper and lower body muscular strength during resistance training of older adults, but potential mechanisms by which creatine exerts these positive effects have yet to be evaluated extensively.