Automated interventricular septum segmentation for black-blood myocardial T2 measurement in thalassemia
Automated interventricular septum segmentation for black-blood myocardial T2 measurement in thalassemia
复制标题
自动室间隔分割用于地中海贫血黑血心肌 T2 测量
DOI：
10.1002/jmri.24662
复制
发表时间：
2015
影响因子：
4.4
通讯作者：
He Taigang
中科院分区：
文献类型：
--
作者：
Zheng Qian;Feng Yanqiu;Wei Xiaping;Feng meiyan;Chen Wufan;Xu Yikai;Chen Hongwen;He Taigang
目的开发并验证一种从心肌黑血图像中提取室间隔（IS）的自动分割方法，用于测量地中海贫血患者的T2*。材料与方法采用1.5 Tesla Siemens Sonata系统（翻转角度20°，采样带宽810 Hz/pixel，体素尺寸1.56 × 1.56 × 10 mm3，视场范围（20 - 30）× 40 cm2，视患者大小而定），对144例地中海贫血重症患者（年龄11-51岁，男性73例）进行黑血多回声梯度序列扫描。改进的Chan - Vese模型通过圆形霍夫变换自动初始化，用于分割左心室（LV）的心内膜和心外膜边缘。因此，通过分析左室与右心室血池的解剖关系，通过强度阈值法识别IS。利用Bland‐Altman分析和变异系数（CoV），将所提出的自动IS分割（AISS）方法与传统的人工方法进行了比较。结果AISS法测量的T2*值与经验丰富的人工测量值吻合较好，平均差值为1.71%，CoV为4.15% （P< 0.001）。结论采用AISS方法可以全自动测量黑血心肌T2*。粉剂。的原因。成像2015;41:1242 - 1250。©2014 Wiley期刊公司
PurposeTo develop and validate an automated segmentation method that extracts the interventricular septum (IS) from myocardial black‐blood images for the T2* measurement in thalassemia patients.Materials and MethodsA total of 144 thalassemia major patients (age range, 11–51 years; 73 males) were scanned with a black‐blood multi‐echo gradient‐echo sequence using a 1.5 Tesla Siemens Sonata system (flip angle 20°, sampling bandwidth 810 Hz/pixel, voxel size 1.56 × 1.56 × 10 mm3and variable fields of view (20–30) × 40 cm2depending on patient size). The improved Chan‐Vese model with an automated initialization by the circular Hough transformation was implemented to segment the endocardial and epicardial margins of the left ventricle (LV). Consequently, the IS was extracted by analyzing the anatomical relation between the LV and the blood pool of the right ventricle, identified by intensity thresholding. The proposed automated IS segmentation (AISS) method was compared with the conventional manual method by using the Bland‐Altman analysis and the coefficient of variation (CoV).ResultsThe T2* measurements using the AISS method were in good agreement with those manually measured by experienced observers with a mean difference of 1.71% and a CoV of 4.15% (P< 0.001).ConclusionBlack‐blood myocardial T2* measurement can be fully automated with the proposed AISS method.J. Magn. Reson. Imaging 2015;41:1242–1250.©2014 Wiley Periodicals, Inc.