Modeling Biological Rhythms in Cell Populations
Modeling Biological Rhythms in Cell Populations
复制标题
细胞群生物节律建模
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. Bernard
中科院分区：
文献类型：
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作者：
R. E. Cheikh;T. Lepoutre;S. Bernard
生物节律发生在生物体的不同层次。在单个细胞中，细胞分裂周期显示出其分子调节因子周期蛋白依赖性激酶（CDK）周期性地调节其活性以确保健康进展的方式的节律性。在组织中，细胞增殖是由生物钟驱动的，生物钟调节细胞周期沿着一天的进展。生物钟通过一个强大的转录-翻译反馈回路网络显示内源性节律，该网络产生持续的振荡。细胞群中的节律性是通过细胞间时钟的协调，通过节律性同步信号来保持的。在这里，我们讨论的机制，产生细胞群体的节奏活动，通过审查一些数学模型，处理他们。我们讨论了组织生长的生物节律的含义和可能应用于时间调节的癌症治疗。
Biological rhythms occur at different levels in the organism. In single cells, the cell division cycle shows rhythmicity in the way its molecular regulators, the cyclin dependant kinases (CDKs), modulate their activity periodically to ensure a healthy progression. In tissues, cell proliferation is driven by the circadian clock, which modulates the progression through the cell cycle along the day. The circadian clock shows endogenous rhythmicity through a robust network of transcription-translation feedback loops that create sustained oscillations. Rhythmicity is preserved in cell populations by the coordination of the clocks among cells, through rhythmic synchronization signals. Here we discuss mechanisms for generating rhythmic activities in cell populations by reviewing some of the mathematical models that deal with them. We discuss the implication of biological rhythms for tissue growth and the possible application to chronomodulated cancer treatments.
影响因子：
3.4
作者：
Becker-Weimann, S;Wolf, J;Kramer, A
通讯作者：
Kramer, A
影响因子：
18.2
作者：
Welsh DK;Takahashi JS;Kay SA
通讯作者：
Kay SA