Single-molecule origin of life scenario: Necessity and feasibility
Single-molecule origin of life scenario: Necessity and feasibility
复制标题
单分子生命起源场景：必要性和可行性
DOI：
10.1016/j.plrev.2021.04.007
复制
发表时间：
2021
影响因子：
11.7
通讯作者：
Mamajanov Irena
中科院分区：
文献类型：
--
作者：
Haotian Liu;Nobutatsu Mochizuki;Chie Kato;Tesfaye Kidane;Ameha Muluneh;Masakazu Fujii;Ryokei Yoshimura;Shin-ichi Kagashima;Yo-ichiro Otofuji;Naoto Ishikawa;Mamajanov Irena
在他们的评论中，d Ischia等人。探索具有黑色素样模体的多环芳烃(PAH)的潜在益生菌来源，讨论黑色素在生物学中的功能，并描述以这些原始黑色素为中心的全面生命起源[1]。在此之前，西蒙·尼古拉斯·普拉茨在2004年提出了相关的PAH世界假说[2]。根据Platts的说法，PAH参与了RNA的合成，从而产生了RNA世界。黑色素样原始多功能实体(Prime)模型建立在生命前化学中扩展的多环芳烃功能的基础上，并为未来的研究提出了一个详细的框架。作者详尽地讨论了描述碳质球粒陨石中发现的不溶有机物(IOM)的分析和结构确定的文献。在参考研究的基础上，作者合理地假设，在生前地球上有充足的IOM供应。IOM中相当大一部分由多环芳烃组成，多环芳烃由两个或三个分散的脂肪族部分组成，使人联想到黑色素结构，而不是扩展的芳香族网络。
In their review, d'Ischia et al. explore the potential prebiotic source of polycyclic aromatic hydrocarbons (PAH) with melanin-like motifs, discuss the functionality of melanin in biology, and describe a comprehensive origin of life scenario centered on these primitive melanins [1]. Previously, Simon Nicholas Platts introduced a related PAH World Hypothesis in 2004 [2]. According to Platts, PAH mediated the synthesis of RNA, bringing about the RNA world. The melanin-like Primordial Multifunctional Entity (PriME) model builds upon extended PAH functionality in prebiotic chemistry and puts forward a detailed framework for future research.The authors exhaustively discuss the literature describing the analysis and structural determination of the insoluble organic matter (IOM) found in carbonaceous chondrites. Based on the referenced research, the authors reasonably assume that IOM was in ample supply on prebiotic Earth. A considerable quotient of the IOM consisted of PAH, the PAH comprised two or three ring systems indispersed with aliphatic moieties, reminiscent of melanin structure, rather than extended aromatic networks.