High ω-6 and low ω-3 fatty acids are associated with depressive symptoms and neuroticism
High ω-6 and low ω-3 fatty acids are associated with depressive symptoms and neuroticism
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DOI：
10.1097/psy.0b013e31815aaa42
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发表时间：
2007-11-01
影响因子：
3.3
通讯作者：
Muldoon, Matthew F.
中科院分区：
文献类型：
--
作者：
Conklin, Sarah M.;Manuck, Stephen B.;Muldoon, Matthew F.
Objective: To examine the concentrations of omega-3 and (omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. Methods: A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory-Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool). Results: Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of ! 10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements. Conclusions: In conjunction with other reports, these findings suggest that the (omega-3 and w-6 fatty acids are related to negative affect at both the symptom and trait levels.
