Anti-apoptotic treatment in mouse models of age-related hearing loss.
Anti-apoptotic treatment in mouse models of age-related hearing loss.
复制标题
年龄相关性听力损失小鼠模型的抗凋亡治疗
DOI：
10.1016/j.joto.2016.03.003
复制
发表时间：
2016-03
影响因子：
1.9
通讯作者：
Cai Q
中科院分区：
文献类型：
--
作者：
Han F;Wang O;Cai Q
老年性听力损失(AHL)，又称老年性耳聋，是最常见的神经退行性疾病，也是老年人最常见的沟通障碍。遗传易感性是AHL发生发展的主要因素之一。一般来说，急性淋巴细胞性白血病与内耳感觉毛细胞、螺旋神经节神经元和血管纹细胞的年龄相关性丢失有关。虽然导致遗传性听力损失的机制还不完全清楚，但caspase家族的蛋白水解酶在内耳病理中起着重要的信号作用。现在公认的是，小鼠模型是研究遗传性听力损失或AHL机制的最好工具。在这里，我们简要回顾了最近通过抗细胞凋亡治疗改善小鼠AHL模型听力的研究。
Age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.